Corticotropin-releasing factor receptor 1 Antibody [CRHR1/14198]

Additional information

Catalog Number: 1394-MSM12
Gene:

Host:

Reactivity:

In Stock

Trial Size Available

Carrier-Free Available

In Stock
Catalog Number Formulation Size Price
1394-MSM12-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
1394-MSM12-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
1394-MSM12-P1ABX
Purified Ab WITHOUT BSA or Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
  • IF

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol
Immunofluorescence (IF) 1-3ug/ml

Product Properties

Antibody Type
Host
Mouse
Applications
Species Reactivity
Clone
CRHR1/14198
Isotype
IgG2b
Light Chain
Kappa
Cellular Localization
Cell membrane, Endosome
Gene Name
Positive Control
Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe
Immunogen
Recombinant fragment (around aa 24-117) of human CRHR1 protein
Purification
Protein G
Storage & Stability
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

Related Antibodies

Other Information

Functions
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
SwissProt
Chromosome Location
17q21.31
Mol. Weight of Antigen
47.67kDa
Alternate Names
Corticotropin-releasing factor receptor 1, CRF-R|CRF-R-1|CRF-R1|CRF1|CRFR-1|CRFR1|CRH-R-1|CRH-R1|CRHR|CRHR1L

Summary

G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.

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