Clathrin, Heavy Chain [CHC/1432]



Recognizes protein of 192kDa, which is identified as Clathrin Heavy Chain. Clathrin is composed of three heavy chains and three light chains, which associate non-covalently to form a triskelion structure. Clathrin heavy chain (HC) is composed of a terminal globular domain, a distal segment and a proximal segment containing a light chain-binding site. The proximal segment of the Clathrin HC protein is essential for interactions between Clathrin heavy chains and light chains, which result in the formation of the triskelion structure.

Product Properties & Targets

Cellular Localization
Coated pit, Cytoplasmic vesicle membrane, Membrane
Light Chain
Gene Name
Positive Control
HeLa cells. Placenta or Prostate Carcinoma.
Recombinant full-length human Clathrin Heavy Chain protein
Alternate Names
Clathrin heavy chain 2, Clathrin heavy chain on chromosome 22, Clathrin heavy chain; Clathrin heavy chain 1; Clathrin heavy chain 2; Clathrin heavy chain on chromosome 17 (CHC17 or CHC-17); CLH22; CLTC; CLTCL; CLTCL1; CLTCL2; CLTD

Database Links

Entrez Gene ID

Additional Information

Human Gene Symbol
Chromosome Location
Mol. Weight of Antigen


  • Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity).

Known Applications & Suggested Dilutions

  • Immunofluorescence (1-2ug/ml)
  • Optimal dilution for a specific application should be determined.

Key References

  • Pearse, B.M. 1987. Clathrin and coated vesicles. EMBO J. 6: 2507-2512.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.


This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.


There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.


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