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Recombinant Cadherin-6 (CDH6) / K-Cadherin Antibody [CDH6/9300R]

Additional information

Catalog Number: 1004-RBM4
Host:

Reactivity:

Gene:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
1004-RBM4-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
1004-RBM4-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
1004-RBM4-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
K-Cadherin Antibody in SDS-PAGE

K-Cadherin Antibody in SDS-PAGE

SDS-PAGE Analysis of Purified CDH6 Recombinant Rabbit Monoclonal Antibody (CDH6/9300R). Confirmation of Purity and Integrity of Antibody.

K-Cadherin Antibody in Immunohistochemistry (IHC (P))

K-Cadherin Antibody in Immunohistochemistry (IHC (P))

Formalin-fixed, paraffin-embedded human kidney stained with CDH6 Recombinant Rabbit Monoclonal Antibody (CDH6/9300R). Inset: PBS instead of primary antibody; secondary only negative control.

  • IHC
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Product Properties

Antibody Type
Recombinant Rabbit Monoclonals
Host
Rabbit
Applications
Immunohistochemistry
Species Reactivity
Human
Clone
CDH6/9300R
Isotype
IgG
Light Chain
Kappa
Cellular Localization
Cell membrane
Gene Name
CDH6
Positive Control
Human kidney or renal cell carcinoma.
Immunogen
Recombinant human Cadherin 6 protein (CDH6) (exact sequence is proprietary)
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Additional information

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Host:

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Additional information

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Host:

Formalin-fixed, paraffin-embedded human Colon stained with Cadherin 17 / CDH17 Mouse Monoclonal Antibody (CDH17/2616).
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Host:

VIEW ALL ANTIBODIES

Other Information

Functions
  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Key References
  • Cadherin-6, a cell adhesion molecule specifically expressed in the proximal renal tubule and renal cell carcinoma. Paul R1, et al. Cancer Res. 1997;57(13):2741-8.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
1004
SwissProt
P55285
Chromosome Location
5p13.3
Mol. Weight of Antigen
130kDa
Alternate Names
Cadherin-6, Kidney cadherin, Cadherin-6; CDH6; CAD6; KCAD;

Summary

This gene encodes a type II classical cadherin from the cadherin superfamily. The encoded membrane protein is a calcium dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Cadherins mediate cell-cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types and the maintenance of orderly structures such as epithelium. Strong transcriptional expression of this gene has been observed in hepatocellular and renal carcinoma cell lines, suggesting a possible role in metastasis and invasion. This protein may play a role in kidney development as well as endometrium and placenta formation. Decreased expression of this gene may be associated with tumor growth and metastasis.

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