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Anti-mouse Cadherin-2 / CDH2 Antibody [CDH2/13882]

Additional information

Catalog Number: 1000-RTM24
Gene:

Host:

Reactivity:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
1000-RTM24-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
1000-RTM24-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
1000-RTM24-P1ABX
Purified Ab WITHOUT BSA or Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
CDH2 Antibody in Western Blot (WB)

CDH2 Antibody in Western Blot (WB)

Western blot analysis of heart tissue lysates from human, mouse, rat and hamster using CDH2 Recombinant Rabbit Monoclonal Antibody (CDH2/13882R).

  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Rat Monoclonals
Host
Rat
Applications
Western Blot
Species Reactivity
Mouse
Clone
CDH2/13882
Isotype
IgG2a
Light Chain
Kappa
Cellular Localization
Adherens junction, Cell junction, Cell membrane, Cell surface, Desmosome, Sarcolemma
Gene Name
CDH2
Immunogen
Recombinant fragment (aa 308–597) corresponding to the extracellular domain of CDH2 protein
Purification
Protein G
Storage & Stability
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. Plays a role in cell-to-cell junction formation between pancreatic beta cells and neural crest stem (NCS) cells, promoting the formation of processes by NCS cells (By similarity). Required for proper neurite branching. Required for pre- and postsynaptic organization (By similarity). CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
1000
SwissProt
P19022
Chromosome Location
18q12.1
Mol. Weight of Antigen
99.81kDa
Alternate Names
Cadherin-2, ACOGS|ADHD8|ARVD14|CD325|CDHN|CDw325|NCAD

Summary

Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. Plays a role in cell-to-cell junction formation between pancreatic beta cells and neural crest stem (NCS) cells, promoting the formation of processes by NCS cells (By similarity). Required for proper neurite branching. Required for pre- and postsynaptic organization (By similarity). CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density.

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