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Recombinant Frataxin (Mitochondrial Marker) Antibody [rFXN/2124]

Additional information

Catalog Number: 2395-MSM6
Reactivity:

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
2395-MSM6-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
2395-MSM6-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
2395-MSM6-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Recombinant Frataxin (Mitochondrial Marker) Antibody

SDS-PAGE Analysis of Purified Frataxin Recombinant Mouse Monoclonal Antibody (rFXN/2124). Confirmation of Purity and Integrity of Antibody.

  • ELISA
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Product Properties

Antibody Type
Mouse Monoclonals, Recombinant Mouse Monoclonals
Host
Mouse
Applications
ELISA
Species Reactivity
Human
Clone
rFXN/2124
Isotype
IgG1
Light Chain
Kappa
Cellular Localization
Cytoplasm, Cytosol, Mitochondrion
Gene Name
FXN
Positive Control
HePG2, HL-60 or HEK293 cells. Pancreas and Liver.
Immunogen
Recombinant human Frataxin protein fragment (around aa 57-210) (exact sequence is proprietary)
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown using heterologous overexpression systems. Modulates the RNA-binding activity of ACO1.
Key References
  • Suebpeng Y, et al. Clin Biochem. 2016 Apr;49(6):463-466.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
2395
SwissProt
Q16595
Chromosome Location
9q21.11
Mol. Weight of Antigen
14kDa
Alternate Names
Frataxin, mitochondrial, Friedreich ataxia protein, CyaY; d-FXN; FARR; Frataxin mature form; Frataxin (81-210); FRDA; Friedreich ataxia protein; Fxn; i-FXN; m56-FXN; m78-FXN; m81-FXN; X25

Summary

Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), a human autosomal recessive neurodegenerative disease. Lack of Frataxin causes iron to accumulate in the mitochondrial matrix suggesting that Frataxin is involved in mitochondrial iron homeostasis and possibly in iron transport. Frataxin has an alpha-beta fold consisting of two helices flanking an antiparallel beta sheet.

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