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IL-4 (Interleukin-4), Mouse Antibody [11B11]

Additional information

Catalog Number: RTM1-2008
Reactivity:

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
RTM1-2008-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
RTM1-2008-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
RTM1-2008-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
IL-4 (Interleukin-4), Mouse Antibody

SDS-PAGE Analysis of Purified IL-4 Rat Monoclonal Antibody (11B11). Confirmation of Integrity and Purity of Antibody.

  • ELISA
  • Flow
  • IF
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Flow Cytometry (Flow) 1-2ug/million cells Flow Cytometry Protocol
Immunofluorescence (IF) 1-3ug/ml

Product Properties

Antibody Type
Rat Monoclonals
Host
Rat
Applications
ELISA, Flow Cytometry, Immunofluorescence
Species Reactivity
Mouse
Clone
11B11
Isotype
IgG1
Light Chain
Kappa
Cellular Localization
Secreted
Gene Name
IL4
Positive Control
Spleen, Thymus or Lymph Node.
Immunogen
Partially Purified native Mouse IL-4
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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VIEW ALL ANTIBODIES

Other Information

Functions
  • Participates in at least several B-cell activation processes as well as of other cell types (PubMed:3083412). It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells (PubMed:3498301). It enhances both secretion and cell surface expression of IgE and IgG1 (PubMed:3498301). It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages (PubMed:25847241). Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4 (PubMed:26416964).
Key References
  • Dzhagalov I, et al. 2007. J. Immunol. 178:2113. (ELISA)
  • Xu G, et al. 2007. J. Immunol. 179:5358. (ELISA)
  • Hara M, et al. 2001. J. Immunol. 166:3789. (Neutralization)
  • Charles N, et al. 2010. Nat. Med. 16:701. (FC)
  • Wang W, et al. 2007. J. Immunol. 178:4885. (Neutralization)
  • Openshaw P, et al. 1995. J. Exp. Med. 182:1357. (ICC)
  • Litton M, et al. 1994. J. Immunol. Methods 175:47. (IHC)
  • Zavorotinskaya T, et al. 2003. Mol. Ther. 7:155. (IP)
  • Fan WY, et al. 2001. Exp. Biol. Med. 226:1045. (IHC)
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
16189
SwissProt
P07750
Chromosome Location
11 B1.3; 11 31.97 cM (Mouse)
Mol. Weight of Antigen
13-14kDa
Alternate Names
Interleukin-4, B-cell IgG differentiation factor, B-cell growth factor 1, B-cell stimulatory factor 1, IGG1 induction factor, Lymphocyte stimulatory factor 1, B cell growth factor 1 (BCGF1); B cell IgG differentiation factor; B-Cell Stimulatory Factor 1 (BSF1); Binetrakin; IGG1 induction factor; IL4; Il4e12; Interleukin 4 variant 2; Interleukin 4, isoform 1; Interleukin-4; Lymphocyte stimulatory factor 1; Pitrakinra

Summary

IL-4 is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. IL-4 is a potent lymphoid cell growth factor, which stimulates the growth and activation of certain B cells and T cells. IL-4 is important for regulation of T helper subset development. IL-4 is expressed primarily by activated Th2 cells and NK cells, and at lower levels by mast cells, and basophils. IL-4 signals through the IL-4R, and dendritic cell IL-12.

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