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Recombinant NKX6.1 (Marker for Pancreatic and Duodenal Neuroendocrine Tumors) Antibody [rNKX61/2561]

In Stock
Catalog Number Formulation Size Price
4825-MSM2-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
4825-MSM2-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
4825-MSM2-P1ABX
Purified Ab WITHOUT BSA or Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
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Summary

Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in the development of insulin-producing beta cells in the islets of Langerhans at the secondary transition (By similarity). Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals (By similarity).

Product Properties & Targets

Antibody Type
Recombinant Mouse Monoclonals
Host
Mouse
Applications
ELISA
Species Reactivity
Human
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Nucleus
Gene Name
NKX6-1
Positive Control
Pancreatic beta cells
Immunogen
Recombinant fragment (around aa227-346) of the human NKX6.1 protein (exact sequence is proprietary)
Alternate Names
Homeobox protein Nkx-6.1, NKX6.1|NKX6A

Database Links

Entrez Gene ID
4825
SwissProt
P78426

Additional Information

Clone
rNKX61/2561
Chromosome Location
4q21.23
Mol. Weight of Antigen
37.85kDa
Expression System
HEK293 Cells
Purification
Protein G

Related Antibodies

View All NKX6-1 Antibodies

Functions

  • Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in the development of insulin-producing beta cells in the islets of Langerhans at the secondary transition (By similarity). Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals (By similarity).

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab produced in a mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
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