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CELA3B / ELA3B (Pancreatic Function Marker) Antibody [157 Amino Acid Residues]

In Stock
Catalog Number Formulation Size Price
23436-RP1
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Flow Cytometry (Flow)
1-2ug/million cells
Immunofluorescence (IF)
1-2ug/ml
Western Blot (WB)
2-4ug/ml

Summary

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein; it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays.

Product Properties & Targets

Antibody Type
Species Reactivity
Research Areas
Positive Control
Pancreas
Immunogen
Recombinant human CELA3B fragment of 157 amino acid residues (aa82-238).
Alternate Names
, Chymotrypsin like elastase family member 3B (CELA3B); ELA3B; Elastase IIIB; Protease E

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
157 Amino Acid Residues
Chromosome Location
1p36.12
Mol. Weight of Antigen
17kDa

Key References

  • Shirasu, Y., et al. 1988. Molecular cloning of complementary DNA encoding one of the human pancreatic protease E isozymes. J. Biochem. 104:259-264.
  • Tani, T., et al. 1988. Identification of a novel class of elastase isozyme, human pancreatic elastase III, by cDNA and genomic gene cloning. J. Biol. Chem. 263: 1231-1239.
  • Shimada, S., et al. 2002. Pancreatic elastase IIIA and its variants are expressed in pancreatic carcinoma cells. Int. J. Mol. Med. 10: 599-603.

Storage & Stability

Recombinant Protein with azide: store at -20 to -80 °C. Recombinant Protein is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This recombinant protein is available for research use only and is not approved for use in diagnosis.

Supplied as

100ug/ml of purified recombinant protein. Prepared in 10mM PBS with 0.05% azide.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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