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Home >> Antibodies >> PDCD1 / PD1 / CD279 (Programmed Cell Death 1)
PDCD1 / PD1 / CD279 (Programmed Cell Death 1)

Recombinant Rabbit Monoclonal Antibody [Clone PDCD1/1410R]

Catalog #
Size
20 ug
100 ug
100 ug
Price (USD)
199.00
429.00
429.00
Formulation
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Catalog No
Size
20 ug
100 ug
100 ug
Formulation
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Price (USD)
199.00
429.00
429.00
img

Formalin-fixed, paraffin-embedded human Tonsil stained with PD1 (CD279) Rabbit Recombinant Monoclonal Antibody (PDCD1/1410R).

img

SDS-PAGE Analysis Purified PD1 (CD279) Rabbit Monoclonal Antibody (PDCD1/1410R).

Product Details

Synonyms

CD279; hPD-1; hSLE1; PD1; PDCD1; Programmed Cell Death Protein 1; Protein PD-1; SLEB2; Systemic lupus erythematosus susceptibility 2

Positive Control

TY cells. Tonsil.

Known Applications & Suggested Dilutions

Flow Cyt, IF, IHC-P         More Details
Flow Cytometry (0.5-1ug/million cells)
Immunofluorescence (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Human full-length recombinant PDCD1 protein

Cellular Localization

Cell Surface & Cytoplasmic

Species Reactivity

Human. Others not known.

Specificity & Comments

PDCD-1 (programmed cell death-1 protein), also designated CD279, is a type I transmembrane receptor and a member of the immunoglobin gene superfamily. It is expressed on activated T-cells, B-cells, and myeloid cells. Anti-PDCD-1 is a marker of angioimmunoblastic lymphoma and suggests a unique cell of origin for this neoplasm. Unlike CD10 and BCL6, PDCD-1 is expressed by few B-cells, so anti-PDCD-1 may be a more specific and useful diagnostic marker in angioimmunoblastic lymphoma. In addition, PDCD-1 expression provides evidence that angioimmunoblastic lymphoma is a neoplasm derived from germinal center-associated T-cells.

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200ug/ml of Ab purified by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Roncador, G., Verdes-Montenegro, J.F.G., Tedoldi, S., Paterson, J.C., Klapper, W., Ballabio, E., Maestre, L., Pileri, S., Hansmann, M.L, Piris, M.A., Mason, D.Y., Marafioti, T. Expression of two markers of germinal center T cells (SAP and PD-1) in angioimmunoblastic T-cell lymphoma. Haematologica. 2007 Aug;92(8):1059-66.

Bioinformatics

  •  Entrez Gene ID: 5133
  •  Gene Symbol: PDCD1
  •  SwissProt: Q15116
  •  Chromosome Location: 2q37.3
  •  Unigene: 158297
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