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Home >> Antibodies >> Parathyroid Hormone (PTH) (N-Terminal)
Parathyroid Hormone (PTH) (N-Terminal)

Recombinant Rabbit Monoclonal Antibody [Clone PTH/1717R]

Catalog #
Size
20 ug
100 ug
100 ug
Price (USD)
199.00
429.00
429.00
Formulation
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Catalog No
Size
20 ug
100 ug
100 ug
Formulation
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Price (USD)
199.00
429.00
429.00
img

Formalin-fixed, paraffin-embedded human Parathyroid stained with PTH Rabbit Recombinant Monoclonal Antibody (PTH/1717R).

img

SDS-PAGE Analysis of Purified PTH Rabbit Recombinant Monoclonal Antibody (PTH/1717R).

Product Details

Synonyms

hPTH; Parathormone; Parathyrin; Parathyroid hormone 1 (PTH1); Parathyroid hormone (PTH)

Positive Control

Human parathyroid gland carcinoma

Known Applications & Suggested Dilutions

Flow Cyt, IF, IHC-P         More Details
Flow Cytometry (0.5-1ug/million cells)
Immunofluorescence (0.5-1ug/ml)
Immunohistochemistry (Formalin-fixed) (0.5-1.0ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human PTH protein N-terminal fragment (exact sequence is proprietary)

Cellular Localization

Cytoplasmic and Secreted

Species Reactivity

Human. Others not known.

Specificity & Comments

Epitope of this MAb maps in the N-terminus of PTH, a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

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200ug/ml of Ab purified by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Watson, P.H. and Hanley, D.A. 1993. Parathyroid hormone: regulation of synthesis and secretion. Clin. Invest. Med. 16: 58-77.

Bioinformatics

  •  Entrez Gene ID: 5741
  •  Gene Symbol: PTH
  •  SwissProt: P01270
  •  Chromosome Location: 11p15.3-p15.1
  •  Unigene: 37045
DOC#01717