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Home >> Antibodies >> Ksp-Cadherin (Kidney-Specific Cadherin) / CDH16
Ksp-Cadherin (Kidney-Specific Cadherin) / CDH16

Recombinant Rabbit Monoclonal Antibody [Clone CDH16/1532R]

Catalog #
Size
20 ug
100 ug
100 ug
Price (USD)
199.00
429.00
429.00
Formulation
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Catalog No
Size
20 ug
100 ug
100 ug
Formulation
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Price (USD)
199.00
429.00
429.00
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Formalin-fixed, paraffin-embedded Human Renal Cell Carcinoma stained with KSP-Cadherin Rabbit Recombinant Monoclonal Antibody (CDH16/1532R)

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Formalin-fixed, paraffin-embedded Rat Kidney stained with KSP-Cadherin Rabbit Recombinant Monoclonal Antibody (CDH16/1532R)

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Formalin-fixed, paraffin-embedded Mouse Kidney Stained with KSP-Cadherin Rabbit Recombinant Monoclonal Antibody (CDH16/1532R)

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SDS-PAGE Analysis of Purified KSP-Cadherin Rabbit Recombinant Monoclonal Antibody (CDH16/1532R). Confirmation of Purity and Integrity of Antibody.

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Western Blot Analysis of human Kidney lysate using KSP-Cadherin Rabbit Recombinant Monoclonal Antibody (CDH16/1532R)

Product Details

Synonyms

Cadherin-16 (CDH16); Kidney-specific cadherin; Ksp-cadherin antibody

Positive Control

Normal kidney or renal cell carcinoma.

Known Applications & Suggested Dilutions

WB, IHC-P         More Details
Western Blotting (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (0.5-1ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA buffer, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human CDH16 protein

Cellular Localization

Cell Surface and Cytoplasmic

Species Reactivity

Human. Mouse. Rat. Others not known.

Specificity & Comments

This MAb recognizes a protein of 130kDa, identified as Ksp-cadherin. Cadherins form a superfamily of related glycoproteins that mediate calcium-dependent cell adhesion and transmit signals from the extracellular matrix to the cytoplasm. Cadherins have been implicated in embryogenesis, tissue morphogenesis, tissue structure maintenance, cell polarization, neoplastic invasiveness and metastasis, and membrane transport. It is suggested that Ksp-cadherin is a marker for terminal differentiation of the basolateral membranes of renal tubular epithelial cells. Within the kidney, Ksp-Cadherin is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells, and not in glomeruli, renal interstitial cells, or blood vessels.Ksp-Cadherin has been suggested to distinguish Chromophobe Renal-Cell Carcinoma from Oncocytoma.

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200ug/ml of Ab purified by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Mazal, P.R., et al. 2005. Expression of kidney-specific cadherin distinguishes chromophobe renal cell carcinoma from renal oncocytoma. Hum Pathol. 36: 22-28.
  2. Shen, S.S., et al. 2005. Kidney-specific cadherin, a specific marker for the distal portion of the nephron and related renal neoplasms. Mod Pathol. 18: 933-40.

Bioinformatics

  •  Entrez Gene ID: 1014
  •  Gene Symbol: CDH16
  •  SwissProt: O75309
  •  Chromosome Location: 16q22.1
  •  Unigene: 513660