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Home >> Antibodies >> Chromogranin A / CHGA (Neuroendocrine Marker)
Chromogranin A / CHGA (Neuroendocrine Marker)

Recombinant Rabbit Monoclonal Antibody [Clone CHGA/1731R]

Catalog #
Size
20 ug
100 ug
100 ug
Price (USD)
199.00
429.00
429.00
Formulation
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Catalog No
Size
20 ug
100 ug
100 ug
Formulation
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Price (USD)
199.00
429.00
429.00
img

Formalin-fixed, paraffin-embedded human Pancreas stained with Chromogranin A Rabbit Recombinant Monoclonal Antibody (CHGA/1731R).

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Formalin-fixed, paraffin-embedded human Parathyroid stained with Chromogranin A Rabbit Recombinant Monoclonal Antibody (CHGA/1731R).

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SDS-PAGE Analysis of Purified Chromogranin A Rabbit Recombinant Monoclonal Antib (CHGA/1731R). Confirmation of Purity and Integrity of Antibody.

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Analysis of Protein Array containing more than 19,000 full-length human proteins using Chromogranin A Rabbit Recombinant Monoclonal Antibody (CHGA/1731R).

Product Details

Synonyms

Beta-Granin; CGA; CHGA; Chromogranin A Parathyroid Secretory Protein 1; ER-37; Pancreastatin; Parastatin; Parathyroid Secretory Protein 1; Pituitary Secretory Protein I; SP-I; Vasostatin I or II

Positive Control

PC12 cells. Adrenal gland, bowel, parathyroid, pancreas, or pheochromocytoma.

Known Applications & Suggested Dilutions

IHC-P         More Details
Immunohistochemistry (Formalin-fixed) (0.5-1.0ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human Chromogranin A (CHGA) protein

Cellular Localization

Finely granular cytoplasmic

Species Reactivity

Human. Others not known.
Does not react with Rat

Specificity & Comments

Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Reportedly, co-expression of certain keratins and chromogranin indicates neuroendocrine lineage. The presence of strong anti-chromogranin staining and absence of anti-keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.

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200ug/ml of Ab purified by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Lloyd RV et. al. Am J Pathol 1988; 130:296-304.
  2. Konecki DS et. al. J Biol Chem 1987;262:17026-30.

Bioinformatics

  •  Entrez Gene ID: 1113
  •  Gene Symbol: CHGA
  •  SwissProt: P10645
  •  Chromosome Location: 14q32.12
  •  Unigene: 150793