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Home >> Antibodies >> CD31 / PECAM-1 (Endothelial Cell Marker)
CD31 / PECAM-1 (Endothelial Cell Marker)

Recombinant Rabbit Monoclonal Antibody [Clone C31/1395R]

Catalog #
Size
20 ug
100 ug
100 ug
Price (USD)
199.00
429.00
429.00
Formulation
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Catalog No
Size
20 ug
100 ug
100 ug
Formulation
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Price (USD)
199.00
429.00
429.00
img

Formalin-fixed, paraffin-embedded human Angiosarcoma stained with CD31 Rabbit Recombinant Monoclonal Antibody (C31/1395R).

img

SDS-PAGE Analysis Purified CD31 Rabbit Recombinant Monoclonal Antibody (C31/1395R). Confirmation of Purity and Integrity of Antibody.

Product Details

Synonyms

EndoCAM; PECA1; Platelet Endothelial Cell Adhesion Molecule 1; GPIIA'

Positive Control

Jurkat cells. Tonsil or Angiosarcoma.

Known Applications & Suggested Dilutions

IHC-P         More Details
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human CD31 protein

Cellular Localization

Cell Surface and Cytoplasmic

Species Reactivity

Human. Others not known.

Host / Ig Isotype

Rabbit / IgG
Mol. Weight of Antigen
~100kDa (endothelium) and ~130kDa (platelets)

Specificity & Comments

CD31 (PECAM-1) is a transmembrane glycoprotein member of the immunoglobulin supergene family of adhesion molecules. CD31 is expressed by stem cells of the hematopoietic system and is primarily used to identify and concentrate these cells for experimental studies as well as for bone marrow transplantation. Anti-CD31 has shown to be highly specific and sensitive for vascular endothelial cells. Staining of nonvascular tumors (excluding hematopoietic neoplasms) is rare. CD31 MAb reacts with normal, benign, and malignant endothelial cells which make up blood vessel lining. The level of CD31 expression can help to determine the degree of tumor angiogenesis, and a high level of CD31 expression may imply a rapidly growing tumor and potentially a predictor of tumor recurrence.

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200ug/ml of Ab purified by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Gratzinger D et. al. Am J Clin Pathol 131:264-278 (2009).

Bioinformatics