Formalin-fixed, paraffin-embedded human Esophageal carcinoma stained with TRIM29 Mouse Monoclonal Antibody (TRIM29/1041).
Formalin-fixed, paraffin-embedded human Lung SqCC stained with TRIM29 Mouse Monoclonal Antibody (TRIM29/1041).
SDS-PAGE Analysis Purified TRIM29 Mouse Monoclonal Antibody (TRIM29/1041). Confirmation of Purity and Integrity of Antibody.
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
It recognizes a 66kDa protein, which is identified as Tripartite motif-containing protein 29 (TRIM29). It interacts with the intermediate filament protein vimentin, a substrate for the PKC family of protein kinases, and with hPKCI-1, an inhibitor of the PKCs. TRIM29 protein contains both zinc finger and leucine zipper motifs, suggesting that the it may form homodimers and possibly associate with DNA. High expression of TRIM29 has been reported in gastric cancer and pancreatic cancer, and correlates with enhanced tumor growth and lymph node metastasis. TRIM29 is also able to distinguish lung squamous cell carcinoma from lung adenocarcinoma with ~90% positive accuracy, when used in a panel with TTF-1, p63, CK5/6, and Napsin-A antibodies.