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Home >> Antibodies >> TRIM29 (Lung Squamous Cell Carcinoma Marker)

TRIM29 (Lung Squamous Cell Carcinoma Marker)

Mouse Monoclonal Antibody [Clone TRIM29/1041]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
img

Formalin-fixed, paraffin-embedded human Esophageal carcinoma stained with TRIM29 Mouse Monoclonal Antibody (TRIM29/1041).

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Formalin-fixed, paraffin-embedded human Lung SqCC stained with TRIM29 Mouse Monoclonal Antibody (TRIM29/1041).

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SDS-PAGE Analysis Purified TRIM29 Mouse Monoclonal Antibody (TRIM29/1041). Confirmation of Purity and Integrity of Antibody.

Product Details

Synonyms

Ataxia telangiectasia group D complementing gene (ATDC); Tripartite motif-containing protein 29 (TRIM29);

Positive Control

Human tonsil or squamous cell carcinoma.

Known Applications & Suggested Dilutions

ELISA, IHC-P         More Details

ELISA (For coating, order Ab without BSA)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment (126 Amino acid residues between aa 1-200) of human TRIM29 protein

Cellular Localization

Cytoplasmic and Cell Surface

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2a, kappa

Mol. Weight of Antigen

66kDa

Specificity & Comments

It recognizes a 66kDa protein, which is identified as Tripartite motif-containing protein 29 (TRIM29). It interacts with the intermediate filament protein vimentin, a substrate for the PKC family of protein kinases, and with hPKCI-1, an inhibitor of the PKCs. TRIM29 protein contains both zinc finger and leucine zipper motifs, suggesting that the it may form homodimers and possibly associate with DNA. High expression of TRIM29 has been reported in gastric cancer and pancreatic cancer, and correlates with enhanced tumor growth and lymph node metastasis. TRIM29 is also able to distinguish lung squamous cell carcinoma from lung adenocarcinoma with ~90% positive accuracy, when used in a panel with TTF-1, p63, CK5/6, and Napsin-A antibodies.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Kosaka Y, et al. Tripartite motif-containing 29 (TRIM29) is a novel marker for lymph node metastasis in gastric cancer. Ann Surg Oncol. 14(9): 2543-9. 2007.
  2. Ring BZ, et al. A novel five-antibody immunohistochemical test for sub-classification of lung carcinoma. Mod Pathol. 22(8): 1032-43. 2009.

Bioinformatics

  •  Entrez Gene ID: 23650
  •  Gene Symbol: TRIM29
  •  SwissProt: Q14134
  •  Chromosome Location: 11q23.3
  •  Unigene: 504115
NBT01041