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Home >> Antibodies >> Transferrin (Early Marker of Oligodendrocytes)

Transferrin (Early Marker of Oligodendrocytes)

Mouse Monoclonal Antibody [Clone TF/3001]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
img

Formalin-fixed, paraffin-embedded human Prostate Carcinoma stained with Transferrin Mouse Monoclonal Antibody (TF/3001).

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SDS-PAGE Analysis Purified Monospecific Mouse Monoclonal Antibody to Transferrin (TF/3001). Confirmation of Integrity and Purity of Antibody.

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Analysis of Protein Array containing >19,000 full-length human proteins using Transferrin Mouse Monoclonal Antibody (TF/3001)

Product Details

Synonyms

Apotransferrin; Beta-1 metal-binding globulin; Serotransferrin; Siderophilin; TF; TFQTL1; Transferrin

Positive Control

Jurkat, HeLa, MCF-7 or K562 cells. Human liver.

Known Applications & Suggested Dilutions

ELISA, IHC-P         More Details

ELISA (Use Ab at 2-4ug/ml for coating) (Order Ab without BSA)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment (around aa 311-445) of human TF protein (exact sequence is proprietary)

Cellular Localization

Secreted

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

79kDa

Specificity & Comments

Iron (Fe) is a tightly metabolically controlled mineral and growth factor present in all living cells. Iron not bound in erythrocyte hemoglobin is transported by transferrin (Tf), the iron transport protein of vertebrate serum. The transferrin protein contains two homologous domains, each of which contain an Fe-binding site. The majority of transferrin is synthesized in the liver and secreted into the blood, but it is also produced in lower amounts in testis and brain as well as in oligodendrocytes, where transferrin is an early marker of oligodendrocyte differentiation. From the blood, transferrin is internalized by erythroblasts and reticulocytes upon binding the transferrin receptor (TfR), also designated CD71, through a system of coated pits and vesicles. After Fe release, transferrin is returned to the extracellular medium, where it can be reused. Defects in the transferrin gene results in atransferrinemia, a rare autosomal recessive disorder characterized by microcytic anemia and iron loading.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Wang Z., et al. Cancer Lett 428:21-33 (2018).

Bioinformatics

  •  Entrez Gene ID: 7018
  •  Gene Symbol: TF
  •  SwissProt: P02787
  •  Chromosome Location: 3q22.1
  •  Unigene: 518267
NBT03001