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Home >> Antibodies >> TIMP1 (Marker of Lymph Node Metastasis)

TIMP1 (Marker of Lymph Node Metastasis)

Mouse Monoclonal Antibody [Clone 2A5]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

219.00
499.00
499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00
499.00
499.00
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SDS-PAGE Analysis of Purified TIMP1 Mouse Monoclonal Antibody (2A5). Confirmation of Integrity and Purity of Antibody.

Product Details

Synonyms

Collagenase inhibitor; EPO; Erythroid-Potentiating Activity (EPA); Fibroblast collagenase inhibitor; Human Collagenase Inhibitor (HCI); Metalloproteinase inhibitor 1; Tissue Inhibitor of Metalloproteinase 1 (TIMP1)

Positive Control

293 cells. Colon Carcinoma.

Known Applications & Suggested Dilutions

ELISA         More Details

ELISA (Use Ab at 2-4ug/ml for coating) (Order Ab without BSA)
Optimal dilution for a specific application should be determined.

Immunogen

A synthetic peptide (aa 72-82) of human TIMP1 protein (FQALGDAADIR)

Cellular Localization

Cytoplasmic and Secreted

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

23kDa

Specificity & Comments

TIMP-1, TIMP-2, TIMP-3 and TIMP-4 (for tissue inhibitor of metalloproteinases -1, -2, -3 and -4) complex with metalloproteinases such as collagenases, gelatinases and stromelysins, resulting in irreversible inactivation of the metalloproteinase. TIMP-1 is identical to EPA (erythroid-potentiation activity). PTH has been shown to be a regulator of TIMP-2 in osteoblastic cells. TIMP-3 may be involved in regulating trophoblastic invasion of the uterus as well as in regulating remodeling of the extracellular matrix during the folding of epithelia, and in the formation, branching and expansion of epithelial tubes. TIMP-4 is most highly expressed in heart tissues. Studies have demonstrated that TIMP1 is useful as a biomarker for early detection of colorectal cancer, outperforming CEA. Additionally, TIMP1 studies have demonstrated its role in CRC tumorigenesis, as well as observing its overexpression in metastatic lymph nodes.

Related Products



200ug/ml of Ab Purified by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Dakubo G.D. 2016. Cancer Biomarkers in Body Fluids. Springer. 509pp.
  2. Song G, et al. Journal of Experimental 35:148.

Bioinformatics

  •  Entrez Gene ID: 7076
  •  Gene Symbol: TIMP1
  •  SwissProt: P01033
  •  Chromosome Location: Xp11.23
  •  Unigene: 522632
NBT01648