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Home >> Antibodies >> TIM3 / HAVCR2 / CD366 (Effector T-Cell Marker)

TIM3 / HAVCR2 / CD366 (Effector T-Cell Marker)

Mouse Monoclonal Antibody [Clone TIM3/3113]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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Formalin-fixed, paraffin-embedded human Adrenal stained with TIM3 Mouse Monoclonal Antibody (TIM3/3113).

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Formalin-fixed, paraffin-embedded human Tonsil stained with TIM3 Mouse Monoclonal Antibody (TIM3/3113).

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Formalin-fixed, paraffin-embedded human Tonsil stained with TIM3 Mouse Monoclonal Antibody (TIM3/3113).

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SDS-PAGE Analysis Purified TIM3 Mouse Monoclonal Antibody (TIM3/3113). Confirmation of Purity and Integrity of Antibody.

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Analysis of Protein Array containing more than 19,000 full-length human proteins using TIM-3 Mouse Monoclonal Antibody (TIM3/3113)

Product Details

Synonyms

CD366; HAVR2; Hepatitis A virus cellular receptor 2 (HAVCR2); Kidney injury molecule 3 (KIM3); T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3; TIM3; TIMD3

Positive Control

PC3, BT474, HepG2, HDLM-2 or Daudi cells. Tonsil, lymph node or spleen.

Known Applications & Suggested Dilutions

ELISA, IHC-P         More Details

ELISA (For coating, order antibody without BSA)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 min at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment of human TIM3 protein (around aa 22-202) (exact sequence is proprietary)

Cellular Localization

Cell Surface

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2a, kappa

Mol. Weight of Antigen

60kDa

Specificity & Comments

TIMs are type I transmembrane glycoproteins with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. TIM-3 is expressed on the surface of effector T cells (CD4+Th1 and CD8+Tc1) but not on helper T cells (CD4+Th2 and CD8+Tc2). In chronic inflammation, autoimmune disorders, and some cancers, TIM-3 is upregulated on several other hematopoietic cell types. The Ig domain of TIM-3 interacts with a ligand on resting but not activated Th1 and Th2 cells. The glycosylated Ig domain of TIM-3 binds cell-associated galectin-9. This induces TIM-3 Tyr phosphorylation and pro-apoptotic signaling. TIM-3 functions as a negative regulator of Th1 cell activity. Its blockade results in increased IFN-gamma production, Th1 cell proliferation and cytotoxicity, regulatory T cell development, and increases in macrophage and neutrophil infiltration into sites of inflammation.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Anderson, A.C. Curr Opin Immunol. 2012 Apr;24(2):213-6.

Bioinformatics

  •  Entrez Gene ID: 84868
  •  Gene Symbol: HAVCR2
  •  SwissProt: Q8TDQ0
  •  Chromosome Location: 5q33.3
  •  Unigene: 710500
NBT03113