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Home >> Antibodies >> STAT5B

STAT5B

Mouse Monoclonal Antibody [Clone STAT5B/2657]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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SDS-PAGE Analysis Purified STAT5B Mouse Monoclonal Antibody (STAT5B/2657). Confirmation of Integrity and Purity of Antibody.

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Analysis of Protein Array containing >19,000 full-length human proteins using STAT5B Mouse Monoclonal Antibody (STAT5B/2657)

Product Details

Synonyms

Signal transducer and activator of transcription 5B; STAT5; Stat5b; Transcription factor STAT5B

Positive Control

Human spleen.

Known Applications & Suggested Dilutions

ELISA         More Details

ELISA (For coating use Ab at 1-5ug/ml, order Ab without BSA) Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human STAT5B protein

Cellular Localization

Cytoplasm & Nucleus. Translocated into the nucleus in response to phosphorylation.

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG

Mol. Weight of Antigen

94kDa

Specificity & Comments

Signal transducer and activator of transcription 5A (Stat5a) and Stat5b, which share 96% homology, undergo receptor tyrosine kinase or G protein-coupled receptor-dependent phosphorylation in response to cytokines or growth factors, and then form homo- or heterodimers that translocate to the nucleus, where they initiate transcription. Activation of Stat5a via IL-2, IL-3, IL-7/ GM-CSF, erythropoietin, thrombopoietin and growth hormones influences proliferation, differentiation and apoptosis in lymphohematopoietic cells. Phosphorylation of Stat5a at Ser127/Ser128 and Ser779 are contigent on ErbB-4-mediated activation of Stat5a. Activation of Stat5b via IL-2, IL-4, CSF-1 and growth hormones influences TCR signaling, apoptosis, adult mammary gland development and sexual dimorphism of liver gene expression. Stat5b is the major liver-expressed Stat5 form that has been shown to fuse with the retinoic acid receptor a gene in acute promyelocytic leukemias (APLL). Stat5a/b null mice have severely impaired lymphoid development and differentiation.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Lin, J.X., et al. 2000. The role of Stat5a and Stat5b in signaling by IL-2 family cytokines. Oncogene 19: 2566-2576.

Bioinformatics

  •  Entrez Gene ID: 6777
  •  Gene Symbol: STAT5B
  •  SwissProt: P51692
  •  Chromosome Location: 17q21.2
  •  Unigene: 595276
NBT02657