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Home >> Antibodies >> StAR (Steroidogenic Acute Regulator) (Leydig Cell Marker)

StAR (Steroidogenic Acute Regulator) (Leydig Cell Marker)

Mouse Monoclonal Antibody [Clone STAR/2077]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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Formalin-fixed, paraffin-embedded human Testis stained with StAR Mouse Monoclonal Antibody (STAR/2077).

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Formalin-fixed, paraffin-embedded human Stomach stained with StAR Mouse Monoclonal Antibody (STAR/2077).

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SDS-PAGE Analysis Purified StAR Mouse Monoclonal Antibody (STAR/2077). Confirmation of Integrity and Purity of Antibody.

Product Details

Synonyms

Cholesterol trafficker; Luteinizing hormone induced protein; Mitochondrial steroid acute regulatory protein; StAR; StAR related lipid transfer (START) domain containing 1; StARD1; START domain-containing protein 1; Steroid acute regulatory protein; Steroidogenic acute regulator (STAR); Steroidogenic acute regulatory protein mitochondrial

Positive Control

K-562 cells. Adrenal or Testicular Carcinoma.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment (around aa 39-108) of human STAR protein (exact sequence is proprietary)

Cellular Localization

Cytoplasmic (Mitochondria)

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2b, kappa

Mol. Weight of Antigen

30kDa

Specificity & Comments

Steroidogenic Acute Regulatory Protein (STAR) controls the rate-limiting step of steroidegenesis by translocating cholesterol from the outer mitochondrial membrane to the inner membrane where it is later cleaved to pregnenolone.It is primarily present in steroid-producing cells, including Leydig cells in the testis, theca cells and luteal cells in the ovary and adrenal cells in the adrenal cortex. Due to low levels of pregnenolone, seminomas and Leydig cell tumors display no specific STAR staining. Therefore, STAR antibody may assist in differentiating sex cord stromal tumors (SCST), seminomas and embryonal carcinomas.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Lin, D., Sugawara, T., Strauss, J.F., 3rd, Clark, B.J., Stocco, D.M., Saenger, P., Rogol, A. and Miller, W.L. 1995. Role of steroidogenic acute regulatory protein in adrenal and gonadal steroidogenesis. Science 267: 1828-1831.
  2. Pollack SE, et al. J Clin Endocrinol Metab. 1997; 82:4343-51.

Bioinformatics

  •  Entrez Gene ID: 6770
  •  Gene Symbol: STAR
  •  SwissProt: P49675
  •  Chromosome Location: 8p11.23
  •  Unigene: 521535
NBT02077