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Home >> Antibodies >> Secretory Component / ECM1

Secretory Component / ECM1

Recombinant Rabbit Monoclonal Antibody [Clone ECM1/2889R]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
img

Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with Secretory Component Rabbit Recombinant Monoclonal (ECM1/2889R).

img

SDS-PAGE Analysis of Purified Secretory Component Rabbit Recombinant Monoclonal (ECM1/2889R). Confirmation of Purity and Integrity of Antibody.

Product Details

Synonyms

ECM1, Extracellular Matrix Protein 1, Secretory Component p85, URBWD

Positive Control

Stomach, Lung or breast tumor.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human full-length ECM1 protein

Cellular Localization

Cell Surface and Cytoplasmic

Species Reactivity

Human. Rat.

Host / Ig Isotype

Rabbit / IgG

Mol. Weight of Antigen

~80kDa

Specificity & Comments

This MAb reacts with a reduction-resistant epitope present in both free and SIgA bound Secretory Component. It does not react with the cell lines lacking secretory component. The antibody is useful for studying the distribution and level of both free and bound secretory component. Secretory component is differentially expressed in epithelium, and the antibody is a popular marker for identifying subpopulations of epithelial cells and epithelial differentiation. The Secretory component antibody is a useful research tool for studying mucosal immunity, inflammation, remodeling, differentiation and tumorigenesis, all processes associated with differential secretory component expression.

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200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Bartek J et. al. Histochemistry 91:235-244 (1989).

Bioinformatics

  •  Entrez Gene ID: 1893
  •  Gene Symbol: ECM1
  •  SwissProt: Q16610
  •  Chromosome Location: 1q21.2
  •  Unigene: 81071
NBT02889