Home >> Antibodies >> Podoplanin (PDPN) (Lymphatic Endothelial & Mesothelial Marker)

Podoplanin (PDPN) (Lymphatic Endothelial & Mesothelial Marker)

Recombinant Mouse Monoclonal Antibody [Clone rPDPN/6994]

Printable

Key References

Bioinformatics

Catalog #

Size

20 ug

100 ug

Price (USD)

219.00

499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Performance Guarantee

Catalog No

Size

20 ug

100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00

499.00

Printable

Key References

Bioinformatics

Formalin-fixed, paraffin-embedded human tonsil stained with Podoplanin Recombinant Mouse Monoclonal Antibody (rPDPN/6994). Inset: PBS instead of primary antibody; secondary only negative control.

SDS-PAGE Analysis Purified Podoplanin Recombinant Mouse Monoclonal Antibody (rPDPN/6994). Confirmation of Integrity and Purity of Antibody.

Formalin-fixed, paraffin-embedded human tonsil stained with Podoplanin Recombinant Mouse Monoclonal Antibody (rPDPN/6994). Inset: PBS instead of primary antibody; secondary only negative control.

SDS-PAGE Analysis Purified Podoplanin Recombinant Mouse Monoclonal Antibody (rPDPN/6994). Confirmation of Integrity and Purity of Antibody.

Product Details

Synonyms

Aggrus; Glycoprotein 36 KD; Glycoprotein 36; gp36; GP38; GP40; HT1A1; hT1alpha1; hT1alpha2; Lung type I cell membrane associated glycoprotein; Lung type I cell membrane associated glycoprotein T1A 2; OTS8;

Positive Control

HeLa cells. Human cervical or lung carcinoma.

Known Applications & Suggested Dilutions

IHC-P More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human Podoplanin (PDPN) protein fragment (around aa 1-100) (exact sequence is proprietary)

Cellular Localization

Cell Surface. Cytoplasm.

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

38-43kDa

Specificity & Comments

It recognizes a muco-protein of 38-43kDa, which is identified as Podoplanin (PDPN). It localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. It is selectively expressed in lymphatic endothelium �as well as lymphoangiomas, �Kaposi sarcomas, �and in a subset of angiosarcomas with probable lymphatic differentiation. Recent studies have also shown podoplanin to be a highly sensitive and relatively specific marker for epithelioid mesothelioma. Therefore, it can be used in a panel to distinguish mesotheliomas or mesothelial cells from pulmonary carcinomas.