Home >> Antibodies >> PGP9.5 / UchL1 (pan-Neuronal Marker)

PGP9.5 / UchL1 (pan-Neuronal Marker)

Mouse Monoclonal Antibody [Clone UCHL1/8152]

Printable

Key References

Bioinformatics

Catalog #

Size

20 ug

100 ug

Price (USD)

219.00

499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Performance Guarantee

Catalog No

Size

20 ug

100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00

499.00

Printable

Key References

Bioinformatics

SDS-PAGE Analysis Purified Pgp9.5 Mouse Monoclonal Antibody (UCHL1/8152). Confirmation of Purity and Integrity of Antibody.

Formalin-fixed, paraffin-embedded human cerebellum stained with Pgp9.5 Mouse Monoclonal Antibody (UCHL1/8152). Inset: PBS instead of primary antibody; secondary only negative control.

Formalin-fixed, paraffin-embedded human pancreas stained with Pgp9.5 Mouse Monoclonal Antibody (UCHL1/8152). HIER: Tris/EDTA, pH9.0, 45min. 2�: HRP-polymer, 30min. DAB, 5min.

SDS-PAGE Analysis Purified Pgp9.5 Mouse Monoclonal Antibody (UCHL1/8152). Confirmation of Purity and Integrity of Antibody.

Formalin-fixed, paraffin-embedded human cerebellum stained with Pgp9.5 Mouse Monoclonal Antibody (UCHL1/8152). Inset: PBS instead of primary antibody; secondary only negative control.

Formalin-fixed, paraffin-embedded human pancreas stained with Pgp9.5 Mouse Monoclonal Antibody (UCHL1/8152). HIER: Tris/EDTA, pH9.0, 45min. 2�: HRP-polymer, 30min. DAB, 5min.

Product Details

Synonyms

Gracile Axonal Dystrophy; Neuron Cytoplasmic Protein 9.5; Park5; Parkinson Disease 5; PGP95; Protein Gene Product 9.5; Ubiquitin Carboxyl-terminal Esterase L1; Ubiquitin Carboxyl-terminal Hydrolase Isozyme L1; Ubiquitin Thioesterase L1; Ubiquitin Thiolesterase L1

Positive Control

Cerebellum

Known Applications & Suggested Dilutions

IHC-P More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment (around aa1-223) of human UCHL1 protein (exact sequence is proprietary)

Cellular Localization

Cytoplasm. Endoplasmic reticulum membrane.

Species Reactivity

Human. Broad species reactivity.

Host / Ig Isotype

Mouse / IgG

Mol. Weight of Antigen

20-30kDa

Specificity & Comments

This MAb reacts with a protein of 20-30kDa, identified as PGP9.5, also known as ubiquitin carboxyl-terminal hydrolase-1 (UchL1). Initially, PGP9.5 expression in normal tissues was reported in neurons and neuroendocrine cells but later it was found in distal renal tubular epithelium, spermatogonia, Leydig cells, oocytes, melanocytes, prostatic secretory epithelium, ejaculatory duct cells, epididymis, mammary epithelial cells, Merkel cells, and dermal fibroblasts. Furthermore, immunostaining for PGP9.5 has been shown in a wide variety of mesenchymal neoplasms as well. A mutation in PGP9.5 gene is believed to cause a form of Parkinson's disease.