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Home >> Antibodies >> PGP9.5 / UchL1

PGP9.5 / UchL1

Mouse Monoclonal Antibody [Clone SPM575]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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Western Blot Analysis of human brain tissue lysate using PGP9.5 / UchL1 Mouse Monoclonal Antibody (SPM575)

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SDS-PAGE Analysis Purified PGP9.5 / UchL1 Mouse Monoclonal Antibody (SPM575). Confirmation of Integrity and Purity of Antibody.

Product Details

Synonyms

Gracile Axonal Dystrophy; Neuron Cytoplasmic Protein 9.5; Park5; Parkinson Disease 5; PGP95; Protein Gene Product 9.5; Ubiquitin Carboxyl-terminal Esterase L1; Ubiquitin Carboxyl-terminal Hydrolase Isozyme L1; Ubiquitin Thioesterase L1; Ubiquitin Thiolesterase L1

Positive Control

Cerebellum.

Known Applications & Suggested Dilutions

Western Blot         More Details

Western Blot (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Native UchL1 (PGP9.5) protein from brain

Cellular Localization

Cytoplasmic. Endoplasmic Reticulum membrane

Species Reactivity

Cow. Dog. Guinea Pig. Human. Mouse. Pig. Rabbit. Rat. Sheep. Zebrafish.

Host / Ig Isotype

Mouse / IgG2a, kappa

Mol. Weight of Antigen

20-30kDa

Specificity & Comments

This MAb reacts with a protein of 20-30kDa, identified as PGP9.5, also known as ubiquitin carboxyl-terminal hydrolase-1 (UchL1). Initially, PGP9.5 expression in normal tissues was reported in neurons and neuroendocrine cells but later it was found in distal renal tubular epithelium, spermatogonia, Leydig cells, oocytes, melanocytes, prostatic secretory epithelium, ejaculatory duct cells, epididymis, mammary epithelial cells, Merkel cells, and dermal fibroblasts. Furthermore, immunostaining for PGP9.5 has been shown in a wide variety of mesenchymal neoplasms as well. A mutation in PGP9.5 gene is believed to cause a form of Parkinson's disease.

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200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Day IN et. al. Biochem Society Trans 14:350-351 (1986)

Bioinformatics

  •  Entrez Gene ID: 7345
  •  Gene Symbol: UCHL1
  •  SwissProt: P09936
  •  Chromosome Location: 4p13
  •  Unigene: 518731
NBT00147