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Home >> Antibodies >> Peroxiredoxin 4 (Prognostic Marker for Lung SqCC)

Peroxiredoxin 4 (Prognostic Marker for Lung SqCC)

Mouse Monoclonal Antibody [Clone CPTC-PRDX4-2]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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SDS-PAGE Analysis Purified Peroxiredoxin 4 Monoclonal Antibody (CPTC-PRDX4-2). Confirmation of Purity and Integrity of Antibody.

Product Details

Synonyms

Antioxidant enzyme AOE372; EC 1.11.1.15; Thioredoxin dependent peroxide reductase A0372; TRANK

Positive Control

HepG2, HeLa and Jurkat cell lysates. Ovarian carcinoma tissue.

Known Applications & Suggested Dilutions

ELISA         More Details

ELISA (For coating, order Ab without BSA)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human PRDX4 protein

Cellular Localization

Cytoplasm. Secreted.

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2b, kappa

Mol. Weight of Antigen

27kDa

Specificity & Comments

The peroxiredoxin (PRX) family comprises six antioxidant proteins, PRX I, II, III, IV, V and VI, which protect cells from reactive oxygen species (ROS) by preventing the metal-catalyzed oxidation of enzymes. The PRX proteins primarily utilize thioredoxin as the electron donor for antioxidation, although they are fairly promiscuous with regard to the hydroperoxide substrate. In addition to protection from ROS, peroxiredoxins are also involved in cell proliferation, differentiation and gene expression. PRX I, II, IV and VI show diffuse cytoplasmic localization, while PRX III and V exhibit distinct mitochondrial localization. The human PRX IV gene is expressed in many tissues. It exists as a precursor protein, which is only detected in testis, and aprocessed secreted form. PRX IV is highly expressed in lung cancer and is necessary for the promotion of lung cancer in vitro. Studies have demonstrated that PRX IV positive expression is significantly correlated with recurrences and shorter disease-free survival in patients with early-stage lung squamous cell carcinoma, and therefore can be used as a prognostic marker in lung squamous cell carcinoma.

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200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Butterfield, L.H., et al. 1999. Antioxid. Redox Signal. 1: 385-402.

Bioinformatics

  •  Entrez Gene ID: 10549
  •  Gene Symbol: PRDX4
  •  SwissProt: Q13162
  •  Chromosome Location: Xp22.11
  •  Unigene: 83383
NBT02483