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Periostin (POSTN)

Recombinant Mouse Monoclonal Antibody [Clone rPOSTN/8522]

Printable

Key References

Bioinformatics

Catalog #

Size

20 ug

100 ug

Price (USD)

219.00

499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Performance Guarantee

Catalog No

Size

20 ug

100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00

499.00

Printable

Key References

Bioinformatics

SDS-PAGE Analysis Purified Periostin Recombinant Mouse Monoclonal Antibody (rPOSTN/8522). Confirmation of Purity and Integrity of Antibody.

Formalin-fixed, paraffin-embedded human prostate stained with Periostin Recombinant Mouse Monoclonal Antibody (rPOSTN/8522). Inset: PBS instead of primary antibody; secondary only negative control.

Formalin-fixed, paraffin-embedded human lung stained with Periostin Recombinant Mouse Monoclonal Antibody (rPOSTN/8522). Inset: PBS instead of primary antibody; secondary only negative control.

SDS-PAGE Analysis Purified Periostin Recombinant Mouse Monoclonal Antibody (rPOSTN/8522). Confirmation of Purity and Integrity of Antibody.

Formalin-fixed, paraffin-embedded human prostate stained with Periostin Recombinant Mouse Monoclonal Antibody (rPOSTN/8522). Inset: PBS instead of primary antibody; secondary only negative control.

Formalin-fixed, paraffin-embedded human lung stained with Periostin Recombinant Mouse Monoclonal Antibody (rPOSTN/8522). Inset: PBS instead of primary antibody; secondary only negative control.

Product Details

Synonyms

Fasciclin-I like; Osteoblast specific factor 2 (OSF2); PDLPOSTN; Periodontal ligament specific periostin; Periostin isoform thy2 / th4 / thy6 / thy8; Periostin osteoblast specific factor; PN; POSTN

Positive Control

Human placenta, breast or colon tissue.

Known Applications & Suggested Dilutions

IHC-P More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment (around aa193-326) of human POSTN protein (exact sequence is proprietary)

Cellular Localization

Secreted. Extracellular space. Extracellular matrix.

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

84/74kDa (Periostin); 90kDa (secreted glycoprotein)

Specificity & Comments

Periostin (PN), also designated osteoblast-specific factor 2 (OSF-2), is a disulfide linked protein originally isolated as a osteoblast-specific factor. Periostin is a secreted protein that binds heparin and functions as a ligand for αVβ3 and αVβ5 integrins. In preosteoblasts, Periostin acts as a cell adhesion molecule and plays a role in osteoblast recruitment, spreading and attachment. Periostin is mainly detected in lower gastrointestinal tract, aorta, stomach, placenta, uterus and breast tissues but is up-regulated in epithelial ovarian tumors and overexpressed in breast cancer. Expression of Periostin is increased by bone morphogenetic protein (BMP2) and transforming growth factor β 1 (TGF β 1). Periostin contains a typical signal sequence, followed by a cysteine-rich domain, a fourfold repeated domain, which shows homology with the insect protein fasciclin, and a C-terminal domain.