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Home >> Antibodies >> Periostin (POSTN)

Periostin (POSTN)

Recombinant Rabbit Monoclonal Antibody [Clone POSTN/8523R]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

219.00
499.00
499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00
499.00
499.00
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SDS-PAGE Analysis Purified Periostin Recombinant Rabbit Monoclonal Antibody (POSTN/8523R). Confirmation of Purity and Integrity of Antibody.

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Formalin-fixed, paraffin-embedded human lung stained with Periostin Recombinant Rabbit Monoclonal Antibody (POSTN/8523R). Inset: PBS instead of primary antibody; secondary only negative control.

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Formalin-fixed, paraffin-embedded human colon stained with Periostin Recombinant Rabbit Monoclonal Antibody (POSTN/8523R). HIER: Tris/EDTA, pH9.0, 45min. 2: HRP-polymer, 30min. DAB, 5min.

Product Details

Synonyms

Fasciclin-I like; Osteoblast specific factor 2 (OSF2); PDLPOSTN; Periodontal ligament specific periostin; Periostin isoform thy2 / th4 / thy6 / thy8; Periostin osteoblast specific factor; PN; POSTN

Positive Control

Human placenta, breast or colon tissue.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment (around aa193-326) of human POSTN protein (exact sequence is proprietary)

Cellular Localization

Secreted. Extracellular space. Extracellular matrix.

Species Reactivity

Human.

Host / Ig Isotype

Rabbit / IgG, kappa

Mol. Weight of Antigen

84/74kDa (Periostin); 90kDa (secreted glycoprotein)

Specificity & Comments

Periostin (PN), also designated osteoblast-specific factor 2 (OSF-2), is a disulfide linked protein originally isolated as a osteoblast-specific factor. Periostin is a secreted protein that binds heparin and functions as a ligand for αVβ3 and αVβ5 integrins. In preosteoblasts, Periostin acts as a cell adhesion molecule and plays a role in osteoblast recruitment, spreading and attachment. Periostin is mainly detected in lower gastrointestinal tract, aorta, stomach, placenta, uterus and breast tissues but is up-regulated in epithelial ovarian tumors and overexpressed in breast cancer. Expression of Periostin is increased by bone morphogenetic protein (BMP2) and transforming growth factor β 1 (TGF β 1). Periostin contains a typical signal sequence, followed by a cysteine-rich domain, a fourfold repeated domain, which shows homology with the insect protein fasciclin, and a C-terminal domain.

Related Products



200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Norris, R.A., et al. 2004. Identification and detection of the Periostin gene in cardiac development. Anat. Rec. A Discov. Mol. Cell. Evol. Biol.281: 1227-1233.

Bioinformatics

  •  Entrez Gene ID: 10631
  •  Gene Symbol: POSTN
  •  SwissProt: Q15063
  •  Chromosome Location: 13q13.3
  •  Unigene: 136348, 721018