Formalin-fixed, paraffin-embedded human colon carcinoma stained with Periostin (POSTN) Mouse Monoclonal Antibody (POSTN/3501).
Formalin-fixed, paraffin-embedded human placenta stained with Periostin (POSTN) Mouse Monoclonal Antibody (POSTN/3501).
SDS-PAGE Analysis Purified Periostin (POSTN) Mouse Monoclonal Antibody (POSTN/3501). Confirmation of Purity and Integrity of Antibody.
Analysis of Protein Array containing more than 19,000 full-length human proteins using Periostin (POSTN)-Monospecific Mouse Monoclonal Antibody (POSTN/3501).
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
Periostin (PN), also designated osteoblast-specific factor 2 (OSF-2), is a disulfide linked protein originally isolated as a osteoblast-specific factor. Periostin is a secreted protein that binds heparin and functions as a ligand for V3 and V5 integrins. In preosteoblasts, Periostin acts as a cell adhesion molecule and plays a role in osteoblast recruitment, spreading and attachment. Periostin is mainly detected in lower gastrointestinal tract, aorta, stomach, placenta, uterus and breast tissues but is up-regulated in epithelial ovarian tumors and overexpressed in breast cancer. Expression of Periostin is increased by bone morphogenetic protein (BMP2) and transforming growth factor 1 (TGF 1). Periostin contains a typical signal sequence, followed by a cysteine-rich domain, a fourfold repeated domain, which shows homology with the insect protein fasciclin, and a C-terminal domain.