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Home >> Antibodies >> PD-L2 / PDCD1LG2 / CD273

PD-L2 / PDCD1LG2 / CD273

Mouse Monoclonal Antibody [Clone PDL2/2676]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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Western Blot Analysis of Raji, HepG2, THP-1, RAW, NIH3T3, U87 cell lysates using PD-L2 Mouse Monoclonal Antibody (PDL2/2676).

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Flow Cytometric Analysis of Jurkat cells using PD-L2 Mouse Monoclonal Antibody (PDL2/2676) followed by Goat anti-Mouse IgG-CF488 (Blue); Isotype Control (Red).

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Immunofluorescence Analysis of Jurkat cells labeling PD-L2 with PD-L2 Mouse Monoclonal Antibody (PDL2/2676) followed by Goat anti-Mouse IgG-CF488 (Green). The nuclear counterstain is Reddot (Red).

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SDS-PAGE Analysis Purified PD-L2 Mouse Monoclonal Antibody (PDL2/2676). Confirmation of Purity and Integrity of Antibody.

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Analysis of Protein Array containing more than 19,000 full-length human proteins using PD-L2 Mouse Monoclonal Antibody (PDL2/2676)

Product Details

Synonyms

B7 dendritic cell molecule; B7-DC; B7DC; Btdc; Butyrophilin B7DC; CD273; PD-L2; PDCD1L2; PDCD1LG2; PDL2; Programmed death ligand 2

Positive Control

Jurakt, HepG2, THP-1, RAW, NIH3T3, U87 cells Placenta or Pancreas. Thyroid Carcinoma.

Known Applications & Suggested Dilutions

ELISA, Flow Cyt, IF, Western Blot         More Details

ELISA (For coating, order antibody without BSA)
Flow Cytometry (1-2ug/million cells)
Immunofluorescence (1-2ug/ml)
Western Blot (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment (around aa 27-220) of human PD-L2 protein (exact sequence is proprietary)

Cellular Localization

Cytoplasmic and Cell Surface

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

31kDa

Specificity & Comments

Recognizes a protein of about 31kDa, which is identified as PD-L2 (same as PDCD1LG2). Engagement of CD28 by B7-1 (CD80) or B7-2 (CD86) in the presence of antigen promotes T cell proliferation, cytokine production, differentiation of effector T cells and the induction of Bcl-x, a promoter of T cell survival. Conversely, engagement of CTLA4 by B7-1 or B7-2 may inhibit proliferation and IL-2 production. PD-L2 does not bind CD28, cytotoxic T lymphocyte A4 or ICOS (inducible co-stimulator). The constitutive expression of PD-L1 and PD-L2 on parenchymal cells of heart, lung and kidney suggests that the Pdcd-1-Pdcd-L system could provide unique negative signaling to help prevent autoimmune disease.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Latchman, Y., et al. 2001. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat. Immun. 2: 261-268.

Bioinformatics

  •  Entrez Gene ID: 80380
  •  Gene Symbol: PDCD1LG2
  •  SwissProt: Q9Q51
  •  Chromosome Location: 9p24.1
  •  Unigene: 532279, 617872
NBT02676