SDS-PAGE Analysis Purified PD-L1 Recombinant Rabbit Monoclonal Antibody (PDL1/8408R). Confirmation of Purity and Integrity of Antibody.
Formalin-fixed, paraffin-embedded human placenta stained with PD-L1 Recombinant Rabbit Monoclonal Antibody (PDL1/8408R). HIER: Tris/EDTA, pH9.0, 45min. 2°: HRP-polymer, 30min. DAB, 5min.
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
PD-L1 is a checkpoint regulator in immune cells, it is expressed on immune or non-hematopoietic cells. Expression of the protein is seen during pregnancy where it has a role in suppressing the immune system. PD-L1 induces an inhibitory signal in activated T-cells and promotes T-cell apoptosis. It is overexpressed in a number of different cancers where it is believed to play a significant role in the cancer s ability to evade the immune system.