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Home >> Antibodies >> PD-L1 / PDCD1LG1 / CD274 / B7-H1 (Cancer Immunotherapy Target)

PD-L1 / PDCD1LG1 / CD274 / B7-H1 (Cancer Immunotherapy Target)

Mouse Monoclonal Antibody [Clone PDL1/2746]

Catalog #

Size

0.5 ml at 100ug/ml

Price (USD)

429.00

Formulation

Purified Ab conjugated to PE

Catalog No

Size

0.5 ml at 100ug/ml

Formulation

Purified Ab conjugated to PE

Price (USD)

429.00
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Flow Cytometric Analysis of human Jurkat cells using PE conjugated PD-L1 Mouse Monoclonal Antibody (PDL1/2746) (blue) Isotype Control (Red).

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SDS-PAGE Analysis Purified PD-L1 Mouse Monoclonal Antibody (PDL1/2746) (unconjugated). Confirmation of Purity and Integrity of Antibody.

Product Details

Synonyms

B7 homolog 1; B7-H1; CD274; PD-L1; PDCD1 ligand 1; PDCD1L1; PDCD1LG1; Programmed cell death 1 ligand 1

Positive Control

Heart, Placenta, Spleen or Tonsil tissue (IF). Jurkat cells (FACS).

Known Applications & Suggested Dilutions

Flow Cyt, IF         More Details

Flow Cytometry (1-2ug/million cells)
Immunofluorescence (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment (around aa 39-191) of human CD274 (PD-L1) protein (exact sequence is proprietary)

Cellular Localization

Cell Surface and Cytoplasmic

Species Reactivity

Human. Mouse.

Host / Ig Isotype

Mouse / IgG2b, kappa

Mol. Weight of Antigen

37-50kDa

Specificity & Comments

PD-L1 is a checkpoint regulator in immune cells, it is expressed on immune or non-hematopoietic cells. Expression of the protein is seen during pregnancy where it has a role in suppressing the immune system. PD-L1 induces an inhibitory signal in activated T-cells and promotes T-cell apoptosis. It is overexpressed in a number of different cancers where it is believed to play a significant role in the cancer s ability to evade the immune system.

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Key References

  1. Dong, H., et al. 1999. Nat. Med. 5: 1365-1369.

Bioinformatics

  •  Entrez Gene ID: 29126
  •  Gene Symbol: CD274
  •  SwissProt: Q9NZQ7
  •  Chromosome Location: 9p24.1
  •  Unigene: 521989
NBT02746