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Home >> Antibodies >> PD1, Mouse

PD1, Mouse

Rat Monoclonal Antibody [Clone RMP1-14]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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SDS-PAGE Analysis Purified PD1 Rat Monoclonal Antibody (RMP-1-14). Confirmation of Integrity and Purity of Antibody.

Product Details

Synonyms

CD279; CD279 antigen; PD1; PDCD1; Programmed cell death 1; Programmed cell death protein 1; Systemic lupus erythematosus susceptibility 2 (SLEB2)

Positive Control

Spleen, Thymus or Lymph Node.

Known Applications & Suggested Dilutions

ELISA, Neut. Studies, Flow Cyt, IF         More Details

ELISA (For coating, order Ab without BSA & Azide)
Neutralization Studies (Order Ab without BSA & Azide)
Flow Cytometry (1-2ug/million cells)
Immunofluorescence (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

PDCD1 transfected BHK cells

Cellular Localization

Cell Surface

Species Reactivity

Mouse. Does not react with Human.

Host / Ig Isotype

Rat / IgG2a, kappa

Mol. Weight of Antigen

50-55kDa

Specificity & Comments

PD-1 is expressed on a subset of CD4-CD8-thymocytes, and on activated T and B cells. PD-1 is thought to be involved in lymphocyte clonal selection and peripheral tolerance. The PD-1 ligands, PD-L1 (also known as B7-H1) and PD-L2 (B7-DC), are members of the B7 immunoglobulin superfamily. PD-1 is transiently expressed on CD4 and CD8 thymocytes as well as activated T and B-lymphocytes and myeloid cells. Additionally,Pdcd1mRNA is expressed in developing B-lymphocytes during the pro-B-cell stage. The RMP1-14 antibody has been reported to block the binding of PD-1 to its ligands (B7-H1 and B7-DC) and to inhibit T cell proliferation and cytokine production co-stimulated by macrophages (but not by dendritic cells and B cells).

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Kanai, T., et al. 2003. J. Immunol. 171:4156. (FC, IHC)
  2. Matsumoto, K., et al. 2004. J. Immunol. 172:2530. (Block)
  3. Yamazaki, T., et al. 2005. J. Immunol. 175:1586. (Costimulation)
  4. Meng, Q., et al. 2006. Invest Opthalmol Vis Sci. 47:444. (FC, WB)
  5. Terrazas, L. I., et al. 2005. Intl. J. Parasitology. 35:1349. (Costimulation)
  6. Takamura S, et al. 2010. J. Immunol. 184:4696. (Block)

Bioinformatics

  •  Entrez Gene ID: 18566
  •  SwissProt: Q02242
  •  Chromosome Location: 1; 1 D (Mouse)
  •  Unigene: 5024
NBT02002