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Home >> Antibodies >> PAX5 / BSAP (Early B-Cell Marker)

PAX5 / BSAP (Early B-Cell Marker)

Mouse Monoclonal Antibody [Clone PAX5/3735]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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Formalin-fixed, paraffin-embedded human Tonsil stained with PAX5 Mouse Monoclonal Antibody (PAX5/3735).

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Analysis of Protein Array containing more than 21,000 full-length human proteins using PAX5 Mouse Monoclonal Antibody (PAX5/3735)

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Formalin-fixed, paraffin-embedded human Tonsil stained with PAX5 Mouse Monoclonal Antibody (PAX5/3735).

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SDS-PAGE Analysis Purified PAX5 Mouse Monoclonal Antibody (PAX5/3735). Confirmation of Purity and Integrity of Antibody.

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Western Blot Analysis of Raji cell lysate using PAX5 Mouse Monoclonal Antibody (PAX5/3735).

Product Details

Synonyms

B cell lineage specific activator; BSAP; EBB-1; KLP; Paired box 5

Positive Control

Daudi or Ramos cells. Human tonsil, spleen, lymph node or colon carcinoma.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 min at RT) (Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

A recombinant fragment (around aa 235-382) of human PAX5 protein (exact sequence is proprietary)

Cellular Localization

Nuclear

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, lambda

Mol. Weight of Antigen

42kDa

Specificity & Comments

The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array, containing more than 21,000, full-length human proteins. The PAX5 gene is a member of thepaired box (PAX)family of transcription factors. The central feature of this gene family is a novel, highly conservedDNA-binding domain, known as thepaired box. The PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute toneoplastic transformation. The PAX5 gene encodes theB-celllineage specific activator protein (BSAP) that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis; therefore, PAX5 gene product may not only play an important role in B-cell differentiation, but also in neural development andspermatogenesis.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Desouki MM, Post GR, Cherry D, Lazarchick J. PAX-5: a valuable immunohistochemical marker in the differential diagnosis of lymphoid neoplasms. Clin Med Res. 2010 Jul;8(2):84-8.

Bioinformatics

  •  Entrez Gene ID: 5079
  •  Gene Symbol: PAX5
  •  SwissProt: Q02548
  •  Chromosome Location: 9p13.2
  •  Unigene: 654464
NBT03735