Formalin-fixed, paraffin-embedded human Parathyroid Gland stained with PTH-Monospecific Recombinant Rabbit Monoclonal Antibody (PTH/2295R).
SDS-PAGE Analysis Purified PTH Monospecific Recombinant Rabbit Monoclonal Antibody (PTH/2295R). Confirmation of Integrity and Purity of the Antibody.
Analysis of Protein Array containing more than 19,000 full-length human proteins using PTH-Monospecific Recombinant Rabbit Monoclonal Antibody (PTH/2295R)
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
Epitope of this MAb maps in between aa 1-34. PTH is a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion.It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.