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Home >> Antibodies >> OX40 / CD134/ TNFRSF4 (Immuno-Oncology Target)

OX40 / CD134/ TNFRSF4 (Immuno-Oncology Target)

Mouse Monoclonal Antibody [Clone OX40/3108]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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Formalin-fixed, paraffin-embedded human Renal Cell Carcinoma stained with OX40 Mouse Monoclonal Antibody (OX40/3108).

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Formalin-fixed, paraffin-embedded human Renal Cell Carcinoma stained with OX40 Mouse Monoclonal Antibody (OX40/3108).

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Immunofluorescence staining of MOLT4 cells using OX40 Mouse Monoclonal Antibody (OX40/3108) followed by goat anti-Mouse IgG conjugated to CF488 (green). Nuclei are stained with Reddot.

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Flow Cytometric Analysis of MOLT4 cells using OX40 Mouse Monoclonal Antibody (OX40/3108) followed by goat anti-Mouse IgG-CF488 (Blue); Isotype Control (Red).

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Formalin-fixed, paraffin-embedded human Tonsil stained with OX40 Mouse Monoclonal Antibody (OX40/3108).

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SDS-PAGE Analysis Purified OX40 Mouse Monoclonal Antibody (OX40/3108). Confirmation of Integrity and Purity of Antibody.

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Analysis of Protein Array containing more than 19,000 full-length human proteins using OX40 Mouse Monoclonal Antibody (OX40/3108).

Product Details

Synonyms

ACT35; CD134; Lymphoid activation antigen ACT35; OX40; TAX transcriptionally-activated glycoprotein 1 receptor; TNFRSF4 (Tumor necrosis factor receptor superfamily member 4)

Positive Control

MOLT-4 cells. Human peripheral blood leukocytes (hPBL). Human tonsil tissue (IHC).

Known Applications & Suggested Dilutions

ELISA, Flow Cyt, IF, IHC-P         More Details

ELISA (For coating, order antibody without BSA)
Flow Cytometry (1-2ug/million cells)
Immunofluorescence (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment of human OX40 (CD134) protein (around aa 59-205) (exact sequence is proprietary)

Cellular Localization

Cell Surface

Species Reactivity

Human. Chimpanzee.

Host / Ig Isotype

Mouse / IgG2c, kappa

Mol. Weight of Antigen

43kDa

Specificity & Comments

ThisMAb recognizes a protein of 43kDa, identified as OX40, which is also known as CD134.OX40 is a type I integral membrane glycoprotein and member of the tumor necrosis factor/nerve growth factor receptor (TNFR/NGFR) family. It is expressed on activated T lymphocytes, hematopoietic precursor cells and fibroblasts. It functions as a T cell co-stimulatory receptor when bound by OX40 Ligand/TNFSF4 that is expressed by antigen presenting cells. OX40 thereby plays roles in T-cell activation as well as the regulation of differentiation, proliferation or apoptosis of normal and malignant lymphoid cells.OX40 is upregulated at the sites of inflammation, especially in case of multiple sclerosis and psoriatic lesions.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Durkop H, et al. 1995. Brit. J. Haematol. 91:927.
  2. Durkop H, et al. 1997. Brit. J. Haematol. 98:863.

Bioinformatics

  •  Entrez Gene ID: 7293
  •  Gene Symbol: TNFRSF4
  •  SwissProt: P43489
  •  Chromosome Location: 1p36.33
  •  Unigene: 129780
NBT03108