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Home >> Antibodies >> NKX6.1 (Marker for Pancreatic and Duodenal Neuroendocrine Tumors)

NKX6.1 (Marker for Pancreatic and Duodenal Neuroendocrine Tumors)

Mouse Monoclonal Antibody [Clone NKX61/2561]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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Formalin-fixed, paraffin-embedded human Pancreas stained with NKX6.1 Mouse Monoclonal Antibody (NKX61/2561).

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SDS-PAGE Analysis Purified NKX6.1 Mouse Monoclonal Antibody (NKX61/2561). Confirmation of Purity and Integrity of Antibody.

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Formalin-fixed, paraffin-embedded human Pancreas stained with NKX6.1 Mouse Monoclonal Antibody (NKX61/2561).

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Analysis of Protein Array containing more than 19,000 full-length human proteins using NKX6.1 Mouse Monoclonal Antibody (NKX61/2561).

Product Details

Synonyms

Homeobox protein NK-6 homolog A; NK homeobox, family 6, A; NK6 homeobox 1; NK6 transcription factor homolog A; NK6 transcription factor related, locus 1 (Drosophila); NKX6-1; NKX6A

Positive Control

Human fetal small intestine lysate or pancreas tissue.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human NKX6.1 protein

Cellular Localization

Nuclear

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2c, kappa

Mol. Weight of Antigen

40-50kDa

Specificity & Comments

Members of the Nkx family of homeodomain proteins are key regulators of growth and development in several tissues, including brain, heart and pancreas. During neural development, sonic hedgehog (Shh) is known to control cell fate and mitogenesis, which is correlated with Shh dose-dependent expression of several genes, including Nkx-6.1. Specifically, Nkx-6.1 is responsible for cellular differentiation in the ventral neural tube and spinal meninges in response to Shh. In the pancreas, Nkx-6.1 is exclusively expressed in the islets of Langerhans in differentiating and mature B cells, which produce Insulin. The presence of Pdx-1 is required for the expression of Nkx-6.1 as well as other pancreatic B cell specific genes, including Insulin, Glut2 and IAPP. Subsequently, Nkx-6.1 binds to the DNA consensus sequence, TTAATTAC, to direct the repression of specific genes in B cells. Nkx6.1 is highly expressed in pancreatic and duodenal well-differentiated neuroendocrine tumors (WDNETS) and in metastatic WDNETS, is a highly specific marker of tumors of pancreatic origin. It has thus been suggested that Nkx6.1 is a useful inclusion into IHC panels for identifying primary sites of WDNETS.

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200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Tseng IC, et al. Am J Surg Pathol. 2015 Jun;39(6):850-7.

Bioinformatics

  •  Entrez Gene ID: 4825
  •  Gene Symbol: NKX6-1
  •  SwissProt: P78426
  •  Chromosome Location: 4q21.23
  •  Unigene: 546270
NBT02561