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Home >> Antibodies >> NKX2.8

NKX2.8

Recombinant Rabbit Monoclonal Antibody [Clone NKX28/3233R]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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Western Blot Analysis of PC3 and MCF-7 cell lysate using NKX2.8 Recombinant Rabbit Monoclonal Antibody (NKX28/3233R).

Product Details

Synonyms

Homeobox protein NK-2 homolog H; NK2 homeobox 8; NK2 transcription factor related, locus 8; Nkx2 9; Nkx2-8; NKX2.8; NKX2G; NKX2H; OTTHUMP00000027959

Positive Control

PC3 or MCF-7 cells. Human Liver, Kidney or Thyroid tissue (IHC).

Known Applications & Suggested Dilutions

ELISA         More Details

ELISA (For coating, order Ab without BSA)
Optimal dilution for a specific application should be determined.

Immunogen

Human recombinant NKX2.8 protein fragment (around aa 10-123) (exact sequence is proprietary)

Cellular Localization

Nucleus and cytoplasm.

Species Reactivity

Human.

Host / Ig Isotype

Rabbit / IgG

Mol. Weight of Antigen

26kDa

Specificity & Comments

The protein encoded by this gene is a homeobox-containing developmental regulator associated with liver development. The encoded protein binds to the alpha-fetoprotein (AFP) gene promoter and increases the expression of AFP. This gene is overexpressed in some lung cancers and is linked to poor patient survival, possibly due to its resistance to cisplatin. This gene is aberrantly methylated in pancreatic cancer, deleted in squamous cell lung carcinomas, and acts as a tumor suppressor in esophageal cancer. Mutations in this gene may also be a cause of neural tube defects.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Regulation of alpha-fetoprotein expression by Nkx2.8. Kajiyama, Y., Tian, J., Locker, J. Mol. Cell. Biol. (2002)

Bioinformatics

  •  Entrez Gene ID: 26257
  •  Gene Symbol: NKX2-8
  •  SwissProt: O15522
  •  Chromosome Location: 14q13.3
  •  Unigene: 234763
NBT03233