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Home >> Antibodies >> NKX2.8

NKX2.8

Mouse Monoclonal Antibody [Clone NKX28/2548]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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SDS-PAGE Analysis Purified NKX2.8 Mouse Monoclonal Antibody (NKX28/2548). Confirmation of Integrity and Purity of Antibody.

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Western Blot Analysis of PC3 and MCF-7 cell lysate using NKX2.8 Mouse Monoclonal Antibody (NKX28/2548).

Product Details

Synonyms

Homeobox protein NK 2 homolog H; Homeobox protein NK-2 homolog H; Homeobox protein Nkx 2.8; Homeobox protein Nkx-2.8; NK 2 homolog 8; NK 2 homolog H; NK2 homeobox 8; NK2 transcription factor related, locus 8; Nkx2 9; Nkx2-8; NKX2.8; NKX28_HUMAN; NKX2G; NKX2H; OTTHUMP00000027959

Positive Control

Human Liver, Kidney or Thyroid tissue (IHC).

Known Applications & Suggested Dilutions

Western Blot, ELISA, Flow Cyt         More Details

Western Blot (2-4ug/ml)
ELISA (For coating, order antibody without BSA)
Flow Cytometry (1-2ug/million cells)
Western Blot (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Human recombinant NKX2.8 protein fragment (around aa 10-123) (exact sequence is proprietary)

Cellular Localization

Nuclear and Cytoplasm.

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

26kDa

Specificity & Comments

The protein encoded by this gene is a homeobox-containing developmental regulator associated with liver development. The encoded protein binds to the alpha-fetoprotein (AFP) gene promoter and increases the expression of AFP. This gene is overexpressed in some lung cancers and is linked to poor patient survival, possibly due to its resistance to cisplatin. This gene is aberrantly methylated in pancreatic cancer, deleted in squamous cell lung carcinomas, and acts as a tumor suppressor in esophageal cancer. Mutations in this gene may also be a cause of neural tube defects.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Regulation of alpha-fetoprotein expression by Nkx2.8. Kajiyama, Y., Tian, J., Locker, J. Mol. Cell. Biol. (2002)

Bioinformatics

  •  Entrez Gene ID: 26257
  •  Gene Symbol: NKX2-8
  •  SwissProt: O15522
  •  Chromosome Location: 14q13.3
  •  Unigene: 234763
NBT02548