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Home >> Antibodies >> NGF-Receptor (p75) / CD271 (Soft Tissue Tumor Marker)

NGF-Receptor (p75) / CD271 (Soft Tissue Tumor Marker)

Mouse Monoclonal Antibody [Clone NGFR5]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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Formalin-fixed, paraffin-embedded human Melanoma stained with NGFR Mouse Monoclonal Antibody (NGFR5).

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Formalin-fixed, paraffin-embedded human Adrenal Gland stained with NGFR Mouse Monoclonal Antibody (NGFR5).

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SDS-PAGE Analysis Purified NGFR Mouse Monoclonal Antibody (NGFR5). Confirmation of Purity and Integrity of Antibody.

Product Details

Synonyms

CD271; Gp80-LNGFR; Low affinity nerve growth factor receptor; Low affinity neurotrophin receptor p75NTR; Nerve growth factor receptor (NGFR); TNFR superfamily member 16; p75 ICD; p75 Neurotrophin receptor; Tumor necrosis factor receptor superfamily member 16 (TNFRSF16)

Positive Control

Neuronal axons, Schwann cells and perineural cells of peripheral nerves or tumors of nerve sheath differentiation e. G. Schwannoma, Neurofibroma. Soma and axons of sensory neurons and ganglionic satellite cells. Melanomas.

Known Applications & Suggested Dilutions

Flow Cyt, IF, IHC-P         More Details

Flow Cytometry (1-2ug/million cells)
Immunofluorescence (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

NGFR from A875 melanoma cells

Cellular Localization

Cell surface and cytoplasmic

Species Reactivity

Human. Monkey. Baboon. Cat. Rabbit. Ferret. Does not react with Mouse or Rat.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

75kDa

Specificity & Comments

It recognizes a glycoprotein of 75kDa, identified as low affinity Nerve Growth Factor (NGF) Receptor (p75NGFR) or Neurotrophin Receptor (p75NTR). Its epitope spans in aa 1-160 of extracellular domain of NGFR/NTR. NGF-receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. NGF is important for the development, differentiation, and survival of variety of neuronal and non-neuronal cells. Its action is mediated by binding two distinct receptors, the high affinity p140 and low affinity p75.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Marano N, et. al. Journal of Neurochemistry, 1987, 48:225-32.

Bioinformatics

  •  Entrez Gene ID: 4804
  •  Gene Symbol: NGFR
  •  SwissProt: P08138
  •  Chromosome Location: 17q21.22
  •  Unigene: 415768, 681726
NBT00890