Formalin-fixed, paraffin-embedded human Melanoma stained with NGFR Rabbit Recombinant Monoclonal Antibody (NGFR/2550R).
SDS-PAGE Analysis Purified NGFR Rabbit Recombinant Monoclonal Antibody (NGFR/2550R). Confirmation of Integrity and Purity of Antibody.
Western Blot Analysis of U87 cell lysate usingNGFR Rabbit Recombinant Monoclonal Antibody (NGFR/2550R).
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
It recognizes a glycoprotein of 75kDa, identified as low affinity Nerve Growth Factor (NGF) Receptor (p75NGFR) or Neurotrophin Receptor (p75NTR). NGFR is expressed in various neural crest cells and their tumors such as melanocytes, melanomas, neuroblastomas, pheochromocytomas and neurofibromas. Reportedly, anti-NGFR is a reliable marker for desmoplastic and neurotropic melanomas. NGFR is expressed in mature non-neural cells such as perivascular cells, dental pulp cells, lymphoidal follicular dendritic cells, basal epithelium of oral mucosa and hair follicles, prostate basal cells, and myoepithelial cells. Anti-NGFR stains the myoepithelial cells of breast ducts and intra-lobular fibroblasts of breast ducts.