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Home >> Antibodies >> NGF-Receptor (p75) / CD271 (Soft Tissue Tumor Marker)

NGF-Receptor (p75) / CD271 (Soft Tissue Tumor Marker)

Recombinant Rabbit Monoclonal Antibody [Clone NGFR/2550R]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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Formalin-fixed, paraffin-embedded human Melanoma stained with NGFR Rabbit Recombinant Monoclonal Antibody (NGFR/2550R).

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SDS-PAGE Analysis Purified NGFR Rabbit Recombinant Monoclonal Antibody (NGFR/2550R). Confirmation of Integrity and Purity of Antibody.

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Western Blot Analysis of U87 cell lysate usingNGFR Rabbit Recombinant Monoclonal Antibody (NGFR/2550R).

Product Details

Synonyms

CD271; Gp80-LNGFR; Low affinity nerve growth factor receptor; Low affinity neurotrophin receptor p75NTR; Nerve growth factor receptor (NGFR); p75 ICD; p75 Neurotrophin receptor; Tumor necrosis factor receptor superfamily member 16 (TNFRSF16)

Positive Control

Neuronal axons, Schwann cells and perineural cells of peripheral nerves or tumors of nerve sheath differentiation e. G. Schwannoma, Neurofibroma. Soma and axons of sensory neurons and ganglionic satellite cells. Melanomas.

Known Applications & Suggested Dilutions

Western Blot, IHC-P         More Details

Western Blot (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human p75 NGFR protein fragment (around aa 281-421) (exact sequence is proprietary)

Cellular Localization

Cell surface and cytoplasmic

Species Reactivity

Human.

Host / Ig Isotype

Rabbit / IgG

Mol. Weight of Antigen

75kDa

Specificity & Comments

It recognizes a glycoprotein of 75kDa, identified as low affinity Nerve Growth Factor (NGF) Receptor (p75NGFR) or Neurotrophin Receptor (p75NTR). NGFR is expressed in various neural crest cells and their tumors such as melanocytes, melanomas, neuroblastomas, pheochromocytomas and neurofibromas. Reportedly, anti-NGFR is a reliable marker for desmoplastic and neurotropic melanomas. NGFR is expressed in mature non-neural cells such as perivascular cells, dental pulp cells, lymphoidal follicular dendritic cells, basal epithelium of oral mucosa and hair follicles, prostate basal cells, and myoepithelial cells. Anti-NGFR stains the myoepithelial cells of breast ducts and intra-lobular fibroblasts of breast ducts.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Soland, T.M., et al. 2008. Nerve growth factor receptor (p75NTR) and pattern of invasion predict poor prognosis in oral squamous cell carcinoma. Histopathology 53: 62-72.
  2. Wang, W., et al. 2009. Patterns of expression and function of the p75NGFR protein in pancreatic cancer cells and tumours. Eur. J. Surg. Oncol. 35: 826-832.

Bioinformatics

  •  Entrez Gene ID: 4804
  •  Gene Symbol: NGFR
  •  SwissProt: P08138
  •  Chromosome Location: 17q21-22
  •  Unigene: 415768, 681726
NBT02550