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Home >> Antibodies >> NECAB1 / N-terminal EF-hand calcium binding protein 1

NECAB1 / N-terminal EF-hand calcium binding protein 1

Mouse Monoclonal Antibody [Clone NECAB1/7676]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

219.00
499.00
499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00
499.00
499.00
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SDS-PAGE Analysis Purified NECAB1 Mouse Monoclonal Antibody (NECAB1/7676). Confirmation of Purity and Integrity of Antibody.

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Formalin-fixed, paraffin-embedded human prostate stained with NECAB1 Mouse Monoclonal Antibody (NECAB1/7676). HIER: Tris/EDTA, pH9.0, 45min. 2: HRP-polymer, 30min. DAB, 5min.

Product Details

Synonyms

EF-hand calcium-binding protein 1; EFCBP1; N-terminal EF-hand calcium-binding protein 1; Neuronal calcium-binding protein 1; STIP-1; synaptotagmin interacting protein 1

Positive Control

Human cerebral cortex.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human NECAB1 protein

Cellular Localization

Cytoplasm.

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG

Mol. Weight of Antigen

41kDa

Specificity & Comments

Members of the EF-CBP (N-terminal EF-hand calcium binding protein)/NECAB (neuronal calcium-binding protein) family participate in neuronal calcium signaling. EF-CBP1 (N-terminal EF-hand calcium binding protein 1), also known as STIP-1 or neuronal calcium-binding protein 1 (NECAB1), is a 351 amino acid cytoplasmic protein that contains one antibiotic biosynthesis monooxygenase (ABM) domain and 2 EF-hand domains. Expressed in brain, EF-CBP1 interacts with copine 6 and Syntaxin, and exists as two alternatively spliced isoforms. The gene encoding EF-CBP1 maps to human chromosome 8, which consists of nearly 146 million base pairs, encodes over 800 genes and is associated with a variety of diseases and malignancies. Schizophrenia, bipolar disorder, Trisomy 8, Pfeiffer syndrome, congenital hypothyroidism, Waardenburg syndrome and some leukemias and lymphomas are thought to occur as a result of defects in specific genes that map to chromosome 8.

Related Products



200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Sugita, S., Ho, A. and Sudhof, T.C. 2002. NECABs: a family of neuronal Ca2+-binding proteins with an unusual domain structure and a restricted expression pattern. Neuroscience 112: 51-63.

Bioinformatics

  •  Entrez Gene ID: 64168
  •  Gene Symbol: NECAB1
  •  SwissProt: Q8N987
  •  Chromosome Location: 8q21.3
  •  Unigene: 642655