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Formalin-fixed, paraffin-embedded human stomach stained with MUC6 Recombinant Rabbit Monoclonal Antibody (MUC6/7069R). HIER: Tris/EDTA, pH9.0, 45min. 2°: HRP-polymer, 30min. DAB, 5min.
Formalin-fixed, paraffin-embedded human salivary gland stained with MUC6 Recombinant Rabbit Monoclonal Antibody (MUC6/7069R). HIER: Tris/EDTA, pH9.0, 45min. 2°: HRP-polymer, 30min. DAB, 5min.
Formalin-fixed, paraffin-embedded human colon carcinoma stained with MUC6 Recombinant Rabbit Monoclonal Antibody (MUC6/7069R). HIER: Tris/EDTA, pH9.0, 45min. 2°: HRP-polymer, 30min. DAB, 5min.
SDS-PAGE Analysis Purified MUC6 Recombinant Rabbit Monoclonal Antibody (MUC6/7069R). Confirmation of Purity and Integrity of Antibody.
Product Details
Synonyms
Positive Control
Known Applications & Suggested Dilutions
Immunogen
Cellular Localization
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Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
The MUC6 gastric mucin is a secreted glycoprotein that plays an essential role in epithelial cyto-protection from acid, proteases, pathogenic microorganisms, and mechanical trauma in the gastrointestinal tract. Mucin 6 expression is highest in the stomach and gall bladder, with lower expression in the terminal ileum and right colon. In gastric cancer, Mucin 6 has an altered expression. In normal stomach, Mucin 6 is associated with Lewis type 2; Mucin 6 is also expressed in gastric metaplasia, duodenum and pancreas. Mucin 6 is a secretory mucin, located in the deeper mucosal folds of human gall bladder, and its expression is altered with increasing degrees of inflammation.
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