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Home >> Antibodies >> MUC5AC (Mucin 5AC / Gastric Mucin)

MUC5AC (Mucin 5AC / Gastric Mucin)

Recombinant Rabbit Monoclonal Antibody [Clone MUC5AC/7068R]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

219.00
499.00
499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00
499.00
499.00
img

Formalin-fixed, paraffin-embedded human stomach stained with MUC5AC Recombinant Rabbit Monoclonal (MUC5AC/7068R)at 2ug/ml. HIER: Tris/EDTA, pH9.0, 45min. 2: HRP-polymer, 30min. DAB, 5min.

img

IHC analysis of formalin-fixed, paraffin-embedded human tonsil. Negative tissue control using MUC5AC/7068R at 2ug/ml in PBS for 30min RT. HIER: Tris/EDTA, pH9.0, 45min. 2: HRP-polymer, 30min. DAB, 5min.

img

SDS-PAGE Analysis Purified MUC5AC Recombinant Rabbit Monoclonal (MUC5AC/7068R). Confirmation of Purity and Integrity of Antibody.

Product Details

Synonyms

Apomucin Major Airway Glycoprotein, Mucin 5 subtype AC tracheobronchial, Mucin 5 Subtypes A And C, Mucin 5AC oligomeric mucus/gel forming, Tracheobronchial Mucin (TBM)

Positive Control

MCF-7 cells.Humanstomach.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human MUC5AC protein

Cellular Localization

Cytoplasm.

Species Reactivity

Human. Predicted to react inMonkey, Rabbit, Cat, Mouse, Rat, Cow and Chicken.

Host / Ig Isotype

Rabbit / IgG

Mol. Weight of Antigen

>1,000kDa

Specificity & Comments

Mucins are a group of high molecular weight glycoproteins consisting of a mucin core protein and O-linked carbohydrates. Mucin 6 carries GlcNAc1 4Gal R structures, indicating that 1, 4-Nacetylglucosaminyltransferase is important to the formation of the mucous glycoproteins in vivo. Mucin 5AC is a gel-forming mucin that is secreted from surface mucous cells. Glucocorticoid is required for the expression of Mucin 5AC mRNA and high doses of hydrocortisone suppresses its expression. Additionally, asthmatic fluid stimulates Mucin 5AC synthesis several-fold. The pro-inflammatory cytokines IL-6 and TNF stimulate Mucin 5AC secretion and thus contribute to the upregulation of mucin by chronic inflammation. Expression of Mucin 5AC is retinoic acid (RA)- or retinol-dependent, and RA control of mucin genes is mediated by the retinoid acid receptor RAR and, to a lesser extent, by RAR. Thyroid hormone binding to thyroid receptors inhibits Mucin 5AC gene expression. Mucin 5AC is also expressed in normal endocervical epithelium, small intestine, gastric cells (Lewis type 1) and gastric metaplasia and it is one of the major mucins in the ethmoid mucosa.

Related Products



200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Int. J. Cancer 47: 304-310 (1991).

Bioinformatics

  •  Entrez Gene ID: 4586
  •  Gene Symbol: MUC5AC
  •  SwissProt: P98088
  •  Chromosome Location: 11p15.5
  •  Unigene: 534332