Formalin-fixed, paraffin-embedded human Kidney stained with MTAP Mouse Monoclonal Antibody (MTAP/1813).
SDS-PAGE Analysis Purified MTAP Mouse Monoclonal Antibody (MTAP/1813). Confirmation of Integrity and Purity of Antibody.
Western Blot Analysis of Human HeLa, A431, HePG2 and HAP1 cell lysate using MTAP Mouse Monoclonal Antibody (MTAP/1813).
Analysis of Protein Array containing more than 19,000 full-length human proteins using MTAP Mouse Monoclonal Antibody (MTAP/1813).
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
Recognizes a protein of 31kDa, which is identified as MTAP (5'-deoxy-5'-methylthioadenosine phosphorylase). It catalyzes the reversible phosphorolysis of methylthioadenosine, which is important in polyamine metabolism and for the salvage of adenine and methionine. The gene encoding MTAP is linked to the tumor suppressor gene, p16INK4A. Deficient levels of MTAP can occur in cancers primarily through co-deletion of the MTAP gene and the p16INK4A gene. Cells expressing MTAP and possessing adenine salvage pathway activity may be less susceptible to malignancy due to growth-inhibitory actions of agents (e.g. antifolates), whose mechanism of action, in part, involves this de novo purine pathway.