2 Union Square, Union City, CA 94587
contact@NeoBiotechnologies.com
510-376-5603

Home >> Antibodies >> MRP3 (Multidrug Resistance-Associated Protein 3)

MRP3 (Multidrug Resistance-Associated Protein 3)

Mouse Monoclonal Antibody [Clone ABCC3/2971]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
img

Formalin-fixed, paraffin-embedded human Pancreatic Carcinoma stained with MRP3 Mouse Monoclonal Antibody (ABCC3/2971).

img

Formalin-fixed, paraffin-embedded human Pancreatic Carcinoma stained with MRP3 Mouse Monoclonal Antibody (ABCC3/2971).

img

Formalin-fixed, paraffin-embedded human Pancreatic Carcinoma stained with MRP3 Mouse Monoclonal Antibody (ABCC3/2971).

img

Analysis of Protein Array containing more than 19,000 full-length human proteins using MRP3 Mouse Monoclonal Antibody (ABCC3/2971).

Product Details

Synonyms

ABC31; ATP-binding cassette sub-family C member 3 (ABCC3); Canalicular multispecific organic anion transporter 2 (CMOAT2); MLP2; MOATD; Multi-specific organic anion transporter D; Multidrug resistance-associated protein 3

Positive Control

Pancreas.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment (around aa 815-957) of human MRP3 (ABCC3) protein (exact sequence is proprietary)

Cellular Localization

Cell Surface

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

169/137/55/32/65kDa

Specificity & Comments

The two members of the large family of ABC transporters known to confer multidrug resistance in human cancer cells are the MDR1 P-glycoprotein and the multidrug-resistance protein MRP1. MRP1 is an integral membrane protein that contains an MDR-like core, an N-terminal membrane-bound region and a cytoplasmic linker, and it is expressed in various cerebral cells, as well as in lung, testis and peripheral blood. The MRP gene family also includes MRP2, which is alternatively designated cMOAT (for canalicular multispecific organic anion transporter) and MRP3, which are both conjugate export pumps exp- ressed predominantly in hepatocytes. MRP2 localizes exclusively to the apical membrane and is constitutively expressed at a high level in normal liver cells. Conversely, MRP3 localizes to the basolateral membrane where it also medi- ates the transport of the organic anion S-(2,4-dinitrophenyl-) glutathione toward the basolateral side of the membrane. MRP3 is normally expressed at comparatively lower levels than MRP2 and increases only when secretion across the apical membrane by MRP2 is impaired.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Konig, J., et al. 1999. Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane. Hepatology 29: 1156-1163.

Bioinformatics

  •  Entrez Gene ID: 8714
  •  Gene Symbol: ABCC3
  •  SwissProt: O15438
  •  Chromosome Location: 17q21.33
  •  Unigene: 463421
NBT02971