2 Union Square, Union City, CA 94587
contact@NeoBiotechnologies.com
510-376-5603

Home >> Antibodies >> MMP3 (Marker of Metastasis and Rheumatoid Arthritis)

MMP3 (Marker of Metastasis and Rheumatoid Arthritis)

Mouse Monoclonal Antibody [Clone MMP3/2655]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
img

Western Blot Analysis of Human Raji, HEK293, and HT-29 cell lysate using MMP3 Mouse Monoclonal Antibody (MMP3/2655).

img

Analysis of Protein Array containing more than 19,000 full-length human proteins using MMP3 Mouse Monoclonal Antibody (MMP3/2655).

Product Details

Synonyms

CHDS6; Matrix metalloproteinase 3; Matrix metalloproteinase-3; MMP3; Proteoglycanase; SL1; STMY1; STR1; Stromelysin-1; Transin 1

Positive Control

Raji, HEK293, HT-29, A431 cells. Prostate or Lung Carcinoma.

Known Applications & Suggested Dilutions

ELISA, Western Blot         More Details

ELISA (For coating, order Ab without BSA)
Western Blot (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment of human MMP3 protein (around aa 236-363) (exact sequence is proprietary)

Cellular Localization

Cytoplasmic and Extracellular Matrix

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2b, kappa

Mol. Weight of Antigen

57kDa

Specificity & Comments

The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-3, MMP-10 and MMP-11 (also designated stromelysin-1, 2 and 3, respectively) activate procollagenase. MMP-3 activation of procollagenase can occur via two pathways. Direct activation by MMP-3 is slow and activation by MMP-3 in conjunction with tissue or plasma proteinases is rapid. MMP-10 is expressed in small intestine, and at lower levels in lung and heart. MMP-11 is specifically expressed in stromal cells of breast carcinomas and contributes to epithelial cell malignancies.

Related Products



200ug/ml of Ab Purified by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Shur, S.A., et al. 1983. The role of cysteinyl residues in the phosphorylase kinase activity as revealed by iodacetamide modification. Biochem. Int. 7: 197-206

Bioinformatics

  •  Entrez Gene ID: 4314
  •  Gene Symbol: MMP3
  •  SwissProt: P08254
  •  Chromosome Location: 11q22.2
  •  Unigene: 375129
NBT02655