Formalin-fixed, paraffin-embedded human Tonsil stained with MCM7 Recombinant Mouse Monoclonal Antibody (rMCM7/1468).
SDS-PAGE Analysis Purified MCM7 Recombinant Mouse Monoclonal Antibody (rMCM7/1468). Confirmation of Integrity and Purity of Antibody.
Western Blot Analysis of MCF-7, HEK-293, A549, SKBr3, HeP2 cell lysates using MCM7 Recombinant Mouse Monoclonal Antibody (rMCM7/1468).
Analysis of Protein Array containing more than 19,000 full-length human proteins using MCM7 Recombinant Mouse Monoclonal Antibody (rMCM7/1468)
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array, containing more than 19,000, full-length human proteins. MCM7 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that is essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumor suppressor protein RB1/RB.