Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with MCM6 Mouse Monoclonal Antibody (MCM6/3000).
SDS-PAGE Analysis Purified MCM6 Mouse Monoclonal Antibody (MCM6/3000). Confirmation of Integrity and Purity of Antibody.
Analysis of Protein Array containing >19,000 full-length human proteins using MCM6 Mouse Monoclonal Antibody (MCM6/3000)
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
The mini-chromosome maintenance (MCM) family of proteins, including MCM2, MCM3, MCM6 (Cdc21), MCM5 (Cdc46), MCM6 (Mis5) and MCM7 (Cdc47), are regulators of DNA replication that act to ensure replication occurs only once in the cell cycle. Expression of MCM proteins increases during cell growth, peaking at G1/S phase. The MCM proteins each contain an ATP-binding motif, which is predicted to mediate ATP-dependent opening of double-stranded DNA. MCM proteins are regulated by E2F transcription factors, which induce MCM expression, and by protein kinases, which interact with MCM proteins to maintain the post-replicative state of the cell. MCM2/MCM6 complexes function as substrates for Cdc2/cyclin B in vitro.