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Home >> Antibodies >> MCM6 (Proliferation Marker)

MCM6 (Proliferation Marker)

Mouse Monoclonal Antibody [Clone MCM6/2999]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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Formalin-fixed, paraffin-embedded human Colon stained with MCM6 Mouse Monoclonal Antibody (MCM6/2999).

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Formalin-fixed, paraffin-embedded human Tonsil stained with MCM6 Mouse Monoclonal Antibody (MCM6/2999).

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Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with MCM6 Mouse Monoclonal Antibody (MCM6/2999).

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SDS-PAGE Analysis Purified MCM6 Mouse Monoclonal Antibody (MCM6/2999). Confirmation of Integrity and Purity of Antibody.

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Analysis of Protein Array containing >19,000 full-length human proteins using MCM6 Mouse Monoclonal Antibody (MCM6/2999)

Product Details

Synonyms

DNA replication licensing factor MCM6; MCM6 minichromosome maintenance deficient 6; MIS5 homolog; p105MCM

Positive Control

Human skin or squamous cell carcinoma (IHC).

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment (around aa 228-368) of human MCM6 protein (exact sequence is proprietary)

Cellular Localization

Nuclear

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2b, kappa

Mol. Weight of Antigen

105kDa

Specificity & Comments

The mini-chromosome maintenance (MCM) family of proteins, including MCM2, MCM3, MCM6 (Cdc21), MCM5 (Cdc46), MCM6 (Mis5) and MCM7 (Cdc47), are regulators of DNA replication that act to ensure replication occurs only once in the cell cycle. Expression of MCM proteins increases during cell growth, peaking at G1/S phase. The MCM proteins each contain an ATP-binding motif, which is predicted to mediate ATP-dependent opening of double-stranded DNA. MCM proteins are regulated by E2F transcription factors, which induce MCM expression, and by protein kinases, which interact with MCM proteins to maintain the post-replicative state of the cell. MCM2/MCM6 complexes function as substrates for Cdc2/cyclin B in vitro.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Koonin, E.V. 1993. Nucleic Acids Res. 21: 2541-25

Bioinformatics

  •  Entrez Gene ID: 4175
  •  Gene Symbol: MCM6
  •  SwissProt: Q14566
  •  Chromosome Location: 2q21.3
  •  Unigene: 444118
NBT02999