Formalin-fixed, paraffin-embedded human tonsil stained with MCM2 Mouse Monoclonal Antibody (MCM2/3678). Inset: PBS instead of primary antibody, secondary only control.
Formalin-fixed, paraffin-embedded human colon carcinoma stained with MCM2 Mouse Monoclonal Antibody (MCM2/3678).
SDS-PAGE Analysis Purified MCM2 Mouse Monoclonal Antibody (MCM2/3678). Confirmation of Purity and Integrity of Antibody.
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array, containing more than 19,000, full-length human proteins. MCM7 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that is essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumor suppressor protein RB1/RB.