SDS-PAGE Analysis of Purified MUC18 Mouse Recombinant Monoclonal Antibody (rMUC18/1130).
Formalin-fixed, paraffin-embedded human Tonsil stained with MUC18 Mouse Recombinant Monoclonal Antibody (rMUC18/1130).
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
Mel-CAM belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. Mel-CAM expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. Mel-CAM is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.